ClinicalTrials.gov

History of Changes for Study: NCT04292899
Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe Coronavirus Disease (COVID-19)
Latest version (submitted December 15, 2020) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 February 28, 2020 None (earliest Version on record)
2 March 10, 2020 Recruitment Status, Study Status, Contacts/Locations and Oversight
3 March 13, 2020 Contacts/Locations and Study Status
4 March 17, 2020 Contacts/Locations and Study Status
5 March 20, 2020 Contacts/Locations and Study Status
6 March 24, 2020 Contacts/Locations and Study Status
7 March 27, 2020 Contacts/Locations and Study Status
8 April 1, 2020 Contacts/Locations and Study Status
9 April 6, 2020 Contacts/Locations, Arms and Interventions, Eligibility, Outcome Measures, Study Status, Study Design and Study Description
10 April 7, 2020 Contacts/Locations and Study Status
11 April 11, 2020 Contacts/Locations and Study Status
12 April 16, 2020 Contacts/Locations, Study Design and Study Status
13 April 17, 2020 Contacts/Locations and Study Status
14 April 20, 2020 Eligibility and Study Status
15 April 21, 2020 Contacts/Locations and Study Status
16 April 28, 2020 Contacts/Locations and Study Status
17 May 5, 2020 Contacts/Locations and Study Status
18 May 12, 2020 Contacts/Locations and Study Status
19 May 29, 2020 Recruitment Status, Contacts/Locations, Study Status and Eligibility
20 July 23, 2020 Recruitment Status, Study Status, Study Design, References and Arms and Interventions
21 December 15, 2020 IPDSharing, Study Status, Outcome Measures, Arms and Interventions, Document Section, Results, Eligibility and Study Identification
Comparison Format:

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Changes (Merged) for Study: NCT04292899
April 11, 2020 (v11) -- April 16, 2020 (v12)

Changes in: Study Status, Study Design and Contacts/Locations

Open or close this module Study Identification
Unique Protocol ID: GS-US-540-5773
Brief Title: Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe Coronavirus Disease (COVID-19)
Official Title: A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe COVID-19
Secondary IDs: 2020-000841-15 [EudraCT Number]
Open or close this module Study Status
Record Verification: April 2020
Overall Status: Recruiting
Study Start: March 6, 2020
Primary Completion: May 2020 [Anticipated]
Study Completion: May 2020 [Anticipated]
First Submitted: February 28, 2020
First Submitted that
Met QC Criteria:
February 28, 2020
First Posted: March 3, 2020 [Actual]
Last Update Submitted that
Met QC Criteria:
April 11 16, 2020
Last Update Posted: April 14 17, 2020 [Actual]
Open or close this module Sponsor/Collaborators
Sponsor: Gilead Sciences
Responsible Party: Sponsor
Collaborators:
Open or close this module Oversight
U.S. FDA-regulated Drug: Yes
U.S. FDA-regulated Device: No
Data Monitoring: Yes
Open or close this module Study Description
Brief Summary: The primary objective of this study is to evaluate the efficacy of 2 remdesivir (RDV) regimens with respect to clinical status assessed by a 7-point ordinal scale on Day 14.
Detailed Description:
Open or close this module Conditions
Conditions: COVID-19
Keywords:
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model: Parallel Assignment
Number of Arms: 4
Masking: None (Open Label)
Allocation: Randomized
Enrollment: 2400 6000 [Anticipated]
Open or close this module Arms and Interventions
Arms Assigned Interventions
Experimental: Part A: Remdesivir (RDV), 5 Days (Not Mechanically Ventilated)
Participants who are not mechanically ventilated will receive continued standard of care therapy together with RDV 200 mg on Day 1 followed by RDV 100 mg on Days 2, 3, 4, and 5.
Drug: Remdesivir
Administered as an intravenous infusion
Other Names:
  • GS-5734™
Drug: Standard of Care
Standard of Care Treatment for COVID-19 Infection
Experimental: Part A: Remdesivir, 10 Days (Not Mechanically Ventilated)
Participants who are not mechanically ventilated will receive continued standard of care therapy together with RDV 200 mg on Day 1 followed by RDV 100 mg on Days 2, 3, 4, 5, 6, 7, 8, 9, and 10.
Drug: Remdesivir
Administered as an intravenous infusion
Other Names:
  • GS-5734™
Drug: Standard of Care
Standard of Care Treatment for COVID-19 Infection
Experimental: Part B: Remdesivir, 5 or 10 Days (Extension)
Part B (Extension) will enroll participants after enrollment to Part A is complete. Participants will receive continued standard of care therapy together with RDV 200 mg on Day 1 followed by RDV 100 mg on Days 2-10.
Drug: Remdesivir
Administered as an intravenous infusion
Other Names:
  • GS-5734™
Drug: Standard of Care
Standard of Care Treatment for COVID-19 Infection
Experimental: Part B: Remdesivir 10 days (Mechanically Ventilated)
Participants on mechanical ventilation will receive continued standard of care therapy together with RDV 200 mg on Day 1 followed by RDV 100 mg on Days 2-10
Drug: Remdesivir
Administered as an intravenous infusion
Other Names:
  • GS-5734™
Drug: Standard of Care
Standard of Care Treatment for COVID-19 Infection
Open or close this module Outcome Measures
Primary Outcome Measures:
1. The Odds of Ratio for Improvement on a 7-point Ordinal Scale on Day 14
[ Time Frame: Day 14 ]

The odds ratio represents the odds of improvement in the ordinal scale between the treatment groups. The ordinal scale is an assessment of the clinical status at a given day. Each day, the worst score from the previous day will be recorded. The scale is as follows: 1. Death 2. Hospitalized, on invasive mechanical ventilation or Extracorporeal Membrane Oxygenation (ECMO) 3. Hospitalized, on non-invasive ventilation or high flow oxygen devices 4. Hospitalized, requiring low flow supplemental oxygen 5. Hospitalized, not requiring supplemental oxygen - requiring ongoing medical care (coronavirus (COVID-19) related or otherwise) 6. Hospitalized, not requiring supplemental oxygen - no longer required ongoing medical care (other than per protocol Remdesivir administration 7. Not hospitalized.
Secondary Outcome Measures:
1. Proportion of Participants Experiencing any Treatment-Emergent Adverse Events
[ Time Frame: First dose date up to 10 days plus 30 days ]

Open or close this module Eligibility
Minimum Age: 12 Years
Maximum Age:
Sex: All
Gender Based:
Accepts Healthy Volunteers: No
Criteria:

Key Inclusion Criteria:

  • Willing and able to provide written informed consent, or with a legal representative who can provide informed consent, or enrolled under International Conference on Harmonization (ICH) E6(R2) 4.8.15 emergency use provisions as deemed necessary by the investigator (age ≥18), or willing and able to provide assent (age ≥12 to <18, where locally and nationally approved) prior to performing study procedures
  • Aged ≥ 18 years (at all sites), or aged ≥ 12 and < 18 years of age weighing ≥ 40 kg (where permitted according to local law and approved nationally and by the relevant institutional review board [IRB] or independent ethics committee [IEC])
  • Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection confirmed by polymerase chain reaction (PCR) test ≤ 4 days before randomization
  • Currently hospitalized
  • Peripheral capillary oxygen saturation (SpO2) ≤ 94% or requiring supplemental oxygen at screening

Key Exclusion Criteria:

  • Participation in any other clinical trial of an experimental treatment for COVID-19
  • Concurrent treatment with other agents with actual or possible direct acting antiviral activity against SARS-CoV-2 is prohibited < 24 hours prior to study drug dosing
  • Evidence of multiorgan failure
  • Mechanically ventilated (including V-V ECMO) ≥ 5 days, or any duration of V-A ECMO.
  • Requiring mechanical ventilation at screening
  • Alanine Aminotransferase (ALT) or aspartate aminotransferase (AST) > 5 X upper limit of normal (ULN)
  • Creatinine clearance < 50 mL/min using the Cockcroft-Gault formula for participants ≥ 18 years of age {Cockcroft 1976} and Schwartz Formula for participants < 18 years of age

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Open or close this module Contacts/Locations
Central Contact Person: Gilead Clinical Study Information Center
Telephone: 1-833-445-3230 (GILEAD-0)
Email: GileadClinicalTrials@gilead.com
Study Officials: Gilead Study Director
Study Director
Gilead Sciences
Locations: United States, California
Kaiser Permanente Los Angeles Medical Center, 3340 E. La Palma Avenue
[Recruiting]
Anaheim, California, United States, 92806
Kaiser Permanente Los Angeles Medical Center, 9333 Imperial Highway
[Recruiting]
Downey, California, United States, 90241
Kaiser Permanente Los Angeles Medical Center, 9961 Sierra Ave
[Recruiting]
Fontana, California, United States, 92335
St Joseph Hospital Eureka
[Recruiting]
Fortuna, California, United States, 95540
Kaiser Permanente Los Angeles Medical Center, 25825 S. Vermont Ave.
[Recruiting]
Harbor City, California, United States, 90710
Kaiser Permanente Los Angeles Medical Center
[Recruiting]
Los Angeles, California, United States, 90027
Kaiser Permanente Los Angeles Medical Center, 6041 Cadillac Ave.
[Recruiting]
Los Angeles, California, United States, 90034
Kaiser Permanente Los Angeles Medical Center, 5601 De Soto Avenue
[Recruiting]
Los Angeles, California, United States, 91365
Kaiser Permanente Los Angeles Medical Center, 10800 Magnolia Avenue
[Recruiting]
Los Angeles, California, United States, 92505
Mission Hospital Regional Medical Center
[Recruiting]
Mission Viejo, California, United States, 92691
Kaiser Permanente Los Angeles Medical Center,27300 Iris Avenue
[Recruiting]
Moreno Valley, California, United States, 92555
El Camino Hospital
[Recruiting]
Mountain View, California, United States, 94040
Hoag Memorial Hospital Presbyterian
[Recruiting]
Newport Beach, California, United States, 92658
Kaiser Permanente Oakland Medical Center
[Recruiting]
Oakland, California, United States, 94611
Kaiser Permanente Los Angeles Medical Center, 2295 S. Vineyard Avenue
[Recruiting]
Ontario, California, United States, 91761
The Center for Cancer Prevention and Treatment at St. Joseph Hospital of Orange
[Recruiting]
Orange, California, United States, 92868
Kaiser Permanente Los Angeles Medical Center,13651 Willard Street
[Recruiting]
Panorama City, California, United States, 91402
Sutter Medical Center Sacramento, One Medical Plaza
[Recruiting]
Roseville, California, United States, 95661
Sutter Medical Center Sacramento
[Recruiting]
Sacramento, California, United States, 95815
Kaiser Permanente Los Angeles Medical Center, 9455 Clairemont Mesa Blvd
[Recruiting]
San Diego, California, United States, 18038
Kaiser Permanente Los Angeles Medical Center, 4647 Zion Avenue
[Recruiting]
San Diego, California, United States, 92120-2507
California Pacific Medical Center-Infectious Disease Associates Medical Group
[Recruiting]
San Francisco, California, United States, 94109
Kaiser Permanente-Oakland, 2425 Geary Blvd
[Recruiting]
San Francisco, California, United States, 94115
Providence St. Johns Medical Center
[Recruiting]
Santa Monica, California, United States, 90404
Sutter Santa Rosa Regional Hospital
[Recruiting]
Santa Rosa, California, United States, 95403
Stanford Hospital
[Recruiting]
Stanford, California, United States, 94305
United States, Colorado
University of Colorado Denver, University of Colorado Hospital
[Recruiting]
Aurora, Colorado, United States, 80045
SCL Health St. Joseph Hospital, 1375 East 19th Ave
[Recruiting]
Denver, Colorado, United States, 80208
SCL Health St. Joseph Hospital
[Recruiting]
Denver, Colorado, United States, 80218
Rose Medical Center
[Recruiting]
Denver, Colorado, United States, 80220
SCL Health St. Joseph Hospital, 200 Exempla Circle.
[Recruiting]
Lafayette, Colorado, United States, 80026
United States, Connecticut
Yale-New Haven Hospital
[Recruiting]
New Haven, Connecticut, United States, 06510
United States, Illinois
John H. Stroger Jr. Hospital of Cook County
[Recruiting]
Chicago, Illinois, United States, 60612
Rush University Medical Center
[Recruiting]
Chicago, Illinois, United States, 60612
University of Chicago
[Recruiting]
Chicago, Illinois, United States, 60637
United States, Indiana
IU Health Methodist Hospital
[Recruiting]
Indianapolis, Indiana, United States, 46077
United States, Iowa
University of Iowa Hospitals & Clinics
[Recruiting]
Iowa City, Iowa, United States, 52242
United States, Louisiana
Tulane University
[Recruiting]
New Orleans, Louisiana, United States, 70112
United States, Maine
Maine Medical Center
[Recruiting]
Portland, Maine, United States, 04102
United States, Maryland
Holy Cross Hospital
[Recruiting]
Silver Spring, Maryland, United States, 20910
United States, Massachusetts
Tufts Medical Center
[Recruiting]
Boston, Massachusetts, United States, 02111
Brigham & Women's Hospital and Harvard Medical School
[Recruiting]
Boston, Massachusetts, United States, 02115
Beth Israel Deaconess Medical Center
[Recruiting]
Boston, Massachusetts, United States, 02215
United States, Michigan
The University of Michigan Hospitals and Health Systems
[Recruiting]
Ann Arbor, Michigan, United States, 48109-5378
Henry Ford Health System
[Recruiting]
Detroit, Michigan, United States, 48202
United States, Minnesota
Hennepin Healthcare
[Recruiting]
Minneapolis, Minnesota, United States, 55415
Mayo Clinic
[Recruiting]
Rochester, Minnesota, United States, 55905
United States, Montana
Providence St Patrick Hospital and International Heart Institute of MT Foundation
[Recruiting]
Missoula, Montana, United States, 59802
United States, New Hampshire
Darmouth-Hitchhock Medical Center
[Recruiting]
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Hackensack University Medical Center
[Recruiting]
Hackensack, New Jersey, United States, 07601
Robert Wood Johnson University Hospital Somerset
[Recruiting]
Hillsborough, New Jersey, United States, 08844
Robert Wood Johnson University Hospital Somerset, 1 RWJ Place
[Recruiting]
New Brunswick, New Jersey, United States, 08901
Robert Wood Johnson University Hospital Somerset, 201 Lyons Avenue
[Recruiting]
Newark, New Jersey, United States, 07112
St. Joseph's University Medical Center
[Recruiting]
Paterson, New Jersey, United States, 07503
United States, New York
Jacobi Medical Center
[Recruiting]
Bronx, New York, United States, 10461
James J. Peters Veterans Administration Medical Center
[Recruiting]
Bronx, New York, United States, 10468
Jamaica Hospital Medical Center
[Recruiting]
Jamaica, New York, United States, 11418
Danbury Hospital
[Recruiting]
Lagrangeville, New York, United States, 12540
North Shore University Hospital, 270-05 76th Ave
[Recruiting]
Manhasset, New York, United States, 11030
North Shore University Hospital
[Recruiting]
Manhasset, New York, United States, 11030
Icahn School of Medicine at Mount Sinai, 350 East 17th Street
[Recruiting]
New York, New York, United States, 10003
Contact:Contact: COVIDGILEAD@mssm.edu
Icahn School of Medicine at Mount Sinai, 440 West 114th St.
[Recruiting]
New York, New York, United States, 10025
Contact:Contact: COVIDGILEAD@mssm.edu
Icahn School of Medicine at Mount Sinai, 1000 10th Avenue
[Recruiting]
New York, New York, United States, 10029
Contact:Contact: COVIDGILEAD@mssm.edu
Icahn School of Medicine at Mount Sinai
[Recruiting]
New York, New York, United States, 10029
Contact:Contact: COVIDGILEAD@mssm.edu
Columbia University Medical Center-New York Presbyterian Hospital
[Recruiting]
New York, New York, United States, 10032
New York Presbyterian Hospital/Weill Cornell Medical Center
[Recruiting]
New York, New York, United States, 10065
United States, North Carolina
Duke University Medical Center
[Recruiting]
Durham, North Carolina, United States, 27710
United States, Ohio
University Hospitals Cleveland Medical Center
[Recruiting]
Cleveland, Ohio, United States, 44106
United States, Oregon
Kaiser Sunnyside Medical Center, 2875 NW Stucki Ave
[Recruiting]
Hillsboro, Oregon, United States, 97124
Providence Portland Medical Center
[Recruiting]
Portland, Oregon, United States, 97213
Providence St. Vincent Medical Center
[Recruiting]
Portland, Oregon, United States, 97225
Kaiser Sunnyside Medical Center
[Recruiting]
Portland, Oregon, United States, 97227
United States, Pennsylvania
Hospital of the University of Pennsylvania, 51 N. 31st Street
[Recruiting]
Philadelphia, Pennsylvania, United States, 19104
Hospital of the University of Pennsylvania
[Recruiting]
Philadelphia, Pennsylvania, United States, 19104
Temple University Hospital
[Recruiting]
Philadelphia, Pennsylvania, United States, 19140
United States, Rhode Island
The Miriam Hospital
[Recruiting]
Providence, Rhode Island, United States, 02906
United States, South Carolina
Prisma Health Richland Hospital
[Recruiting]
Columbia, South Carolina, United States, 29203
United States, Texas
The Liver Institute of Methodist Dallas Medical Center
[Recruiting]
Dallas, Texas, United States, 75203
UT Southwestern Medical Center Amelia Court, HIV Research Clinic
[Recruiting]
Dallas, Texas, United States, 75235
Baylor University Medical Center
[Recruiting]
Dallas, Texas, United States, 75246
UT Southwestern Medical Center Amelia Court, HIV Research Clinic, 5201 Harry Hines Blvd.
[Recruiting]
Dallas, Texas, United States, 75390
UT Southwestern Medical Center Amelia Court, HIV Research Clinic, 6201 Harry Hines Blvd
[Recruiting]
Dallas, Texas, United States, 75390
Baylor University Medical Center, 1400 8th Ave
[Recruiting]
Fort Worth, Texas, United States, 76104
Houston Methodist Hospital
[Recruiting]
Houston, Texas, United States, 77030
Baylor University Medical Center, 2401 S. 31st St.
[Recruiting]
Temple, Texas, United States, 76508
United States, Utah
University of Utah Health
[Recruiting]
Salt Lake City, Utah, United States, 84132
United States, Virginia
Virginia Hospital Center
[Recruiting]
Arlington, Virginia, United States, 22205
Inova Fairfax Medical Campus
[Recruiting]
Falls Church, Virginia, United States, 22042
VCU Health Medical Center
[Recruiting]
Richmond, Virginia, United States, 23298
United States, Washington
Providence Regional Medical Center Everett
[Recruiting]
Everett, Washington, United States, 98201
Kadlec Regional Medical Center
[Recruiting]
Kennewick, Washington, United States, 99336
Providence St. Peter Hospital
[Recruiting]
Olympia, Washington, United States, 98506
Virginia Mason Medical Center
[Recruiting]
Seattle, Washington, United States, 98101
Swedish Center for Comprehensive Care
[Recruiting]
Seattle, Washington, United States, 98104
MultiCare Deaconess Hospital
[Recruiting]
Spokane, Washington, United States, 99204
MultiCare Tacoma General Hospital
[Recruiting]
Tacoma, Washington, United States, 98405
St Joseph Medical Center
[Recruiting]
Tacoma, Washington, United States, 98405
France
CHU de BORDEAUX
[Recruiting]
Bordeaux, France, 33076
Chu Montpellier
[Recruiting]
Montpelier Cedex 5, France, 34295
CHU de Nantes
[Recruiting]
Nantes, France, 44035
Saint Louis hospital
[Recruiting]
Paris, France, 75010
Hopital Saint Antoine
[Recruiting]
Paris, France, 75012
Germany
Charite Universitatsmedizin Berlin, Campus Virchow-Klinikum, Medizinische Klinik Infektiologie Pneumologie
[Recruiting]
Berlin, Germany, 13353
Germany
Universitatsklinikum Hamburg-Eppendorf
[Recruiting]
Hamburg, Germany, 20246
Universitätsklinikum Schleswig-Holstein Campus Kiel
[Recruiting]
Kiel, Germany, 24105
Klinikum St. Georg gGmbH Klinik fur Infektiologie, Tropenmedizin, Nephrologie und Rheumatologie
[Recruiting]
Leipzig, Germany, 4129
Klinikum rechts der Isar der TU Munchen, Klinik und Poliklinik Innere Medizin 2
[Recruiting]
Munich, Germany, 81675
Klinik für Hämatologie, Onkologie, Immunologie
[Recruiting]
München, Germany, 80804
Robert-Bosch-Krankenhaus (RBK), Klinik Schillerhohe (KSH) und Dr. Margarete Fischer-Bosch-Institut fur klinische Pharmakologie (IKP)
[Recruiting]
Stuttgart, Germany, 70376
Germany, WA
Universitatsklinikum Dusseldorf, Klinik fur Gastroenterologie, Hepatologie und Infektiologie
[Recruiting]
Düsseldorf, WA, Germany, 40225
Hong Kong
Prince of Wales Hospital
[Recruiting]
Hong Kong, Hong Kong
Princess Margaret Hospital
[Recruiting]
Hong Kong, Hong Kong
Queen Mary Hospital
[Recruiting]
Hong Kong, Hong Kong
Italy
Clinica Universitaria Malattie Infettive, Ospedale Amedeo di Savoia
[Recruiting]
Bergamo, Italy, 24127
Italy
ASST degli Spedali Civili di Brescia
[Recruiting]
Brescia, Italy, 25123
ASST di Cremona - Azienda Socio Sanitaria Territor
[Recruiting]
Cremona, Italy, 26100
UO Malattie Infettive, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
[Recruiting]
Milan, Italy, 20122
UOC Malattie Infettive, IRCCS Ospedale San Raffaele
[Recruiting]
Milano, Italy, 20127
Dipartimento di Malattie Infettive, Malattie Infettive I- Malattie Infettive III, AssT Fatebenefratelli Sacco Ospedale Luigi Sacco
[Recruiting]
Milano, Italy, 20157
UOC Medicina Di Laboratorio, Azienda Ospedaliera di Padova
[Recruiting]
Padova PD, Italy, 35121
Azienda Ospedaliero Universitaria di Parma
[Recruiting]
Parma, Italy, 43126
UOC Malattie Infettive I, Fondazione IRCCS Policlinio San Matteo
[Recruiting]
Pavia, Italy, 27100
Ospedale Guglielmo da Saliceto AUSL di Piacenza
[Recruiting]
Piacenza, Italy
UOC Malattie Infettive ad Alta Intensita di Cure, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani I.R.C.C.S.
[Recruiting]
Roma, Italy, 00149
Clinica Universitaria Malattie Infettive, Ospedale Amedeo di Savoia
[Recruiting]
Torino, Italy, 10149
Japan
Yokohama Municipal Citizen's Hospital
[Recruiting]
Kanagawa, Japan, 240-8555
Nagoya City Easter Medical Center
[Recruiting]
Nagoya, Japan, 464-8547
Tokyo Metropolitan Bokutoh Hospital
[Recruiting]
Tokyo, Japan, 130-8575
Korea, Republic of
Kyungpook National University Hospital
[Recruiting]
Daegu, Korea, Republic of, 41944
Seoul Medical Center
[Recruiting]
Seoul, Korea, Republic of, 02053
National Medical Center
[Recruiting]
Seoul, Korea, Republic of, 04564
Netherlands
Amsterdam University Medical Centre - Location AMC
[Recruiting]
Amsterdam, Netherlands, 1105 AZ
Netherlands
Leiden University Medical Center
[Recruiting]
Leiden, Netherlands, 2300 RC
Erasmus Medical Centre
[Recruiting]
Rotterdam, Netherlands, 3015 GD
Singapore
National University Hospital
[Recruiting]
Singapore, Singapore, 119228
Singapore General Hospital
[Recruiting]
Singapore, Singapore, 169856
National Centre for Infectious Diseases, Tan Tock Seng Hospital
[Recruiting]
Singapore, Singapore, 308442
Spain
Hospital Universitari Vall d'Hebron
[Recruiting]
Barcelona, Spain, 08035
Hospital Clinic de Barcelona
[Recruiting]
Barcelona, Spain, 8036
Hospital Universitario Cruces
[Recruiting]
Bizkaia, Spain, 48903
Hospital Universitario Ramón y Cajal
[Recruiting]
Madrid, Spain, 28034
Hospital Universitario 12 de Octubre
[Recruiting]
Madrid, Spain, 28041
Hospital Universitario La Paz
[Recruiting]
Madrid, Spain, 28046
Hospital Regional Universitario de Málaga
[Recruiting]
Málaga, Spain, 29010
Spain, Madrid
Hospital Principe de Asturias
[Recruiting]
Alcalá De Henares, Madrid, Spain, 28805
Sweden
Sahlgrenska University Hospital, Ostra
[Recruiting]
Gothenburg, Sweden, 41685
SUS (Skanes University Hospital)
[Recruiting]
Malmo, Sweden, 20502
Karolinska University Hospital
[Recruiting]
Stockholm, Sweden, SE-141 86
Switzerland
Hopitaux Universitaires de Genève
[Recruiting]
Genève 14, Switzerland, 1211
Ospedale Regionale di Locarno La Carità
[Recruiting]
Lugano, Switzerland, CH- 6900
Universitätsspital Zürich
[Recruiting]
Zürich, Switzerland, 8091
Taiwan
Kaohsiung Veterans General Hospital
[Recruiting]
Kaohsiung, Taiwan, 81362
China Medical University Hospital
[Recruiting]
Taichung, Taiwan, 40447
National Taiwan University Hospital
[Recruiting]
Taipei City, Taiwan, 10002
United Kingdom
Royal Infirmary of Edinburgh
[Recruiting]
Edinburgh, United Kingdom, EH4 2XU
United Kingdom
Queen Elizabeth University Hospital
[Recruiting]
Glasgow, United Kingdom, G51 4TF
Hull University Teaching Hospitals NHS Trust
[Recruiting]
Hull, United Kingdom, HU16 5JQ
Royal Lancaster Hospital
[Recruiting]
Lancaster, United Kingdom, LA1 4RP
Liverpool University Hospital
[Recruiting]
Liverpool, United Kingdom, L7 8XP
Northwick Park Hospital
[Recruiting]
London, United Kingdom, HA1 3UJ
Royal Free London NHS Foundation Trust
[Recruiting]
London, United Kingdom, NW3 2QG
King's College Hospital NHS Trust
[Recruiting]
London, United Kingdom, SE5 9RS
University Imperial College London Healthcare NHS Trust
[Recruiting]
London, United Kingdom, WC W2 1 E 6JF NY
University College London
[Recruiting]
London, United Kingdom, WC1E 6JF
Manchester Royal
[Recruiting]
Manchester, United Kingdom, M13 9WL
Manchester University NHS Foundation Trust
[Recruiting]
Manchester, United Kingdom, M23 9LT
Pennine Acute Hospitals NHS Trust
[Recruiting]
Manchester, United Kingdom, M8 5RB
Derriford Hospital
[Recruiting]
Plymouth, United Kingdom, PL6 8BG
Sheffield Teaching Hospitals
[Recruiting]
Sheffield, United Kingdom, S10 2JF
Open or close this module IPDSharing
Plan to Share IPD: No
Open or close this module References
Links:
Available IPD/Information:

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