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History of Changes for Study: NCT01265849
Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity (IT-MATTERS)
Latest version (submitted September 28, 2019) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 December 22, 2010 Nothing (earliest Version on record)
2 December 23, 2010 Study Status, Arms and Interventions and Study Description
3 December 24, 2010 Study Status
4 May 2, 2011 Contacts/Locations, Conditions and Study Status
5 May 4, 2011 Contacts/Locations and Study Status
6 May 16, 2011 Study Status and Contacts/Locations
7 May 18, 2011 Eligibility and Study Status
8 May 31, 2011 Contacts/Locations and Study Status
9 June 13, 2011 Study Status and Contacts/Locations
10 June 28, 2011 Contacts/Locations and Study Status
11 June 30, 2011 Contacts/Locations and Study Status
12 July 8, 2011 Contacts/Locations and Study Status
13 July 11, 2011 Contacts/Locations and Study Status
14 August 1, 2011 Contacts/Locations and Study Status
15 August 2, 2011 Contacts/Locations and Study Status
16 August 23, 2011 Contacts/Locations, Sponsor/Collaborators and Study Status
17 August 30, 2011 Contacts/Locations and Study Status
18 September 9, 2011 Contacts/Locations and Study Status
19 September 12, 2011 Contacts/Locations and Study Status
20 September 16, 2011 Contacts/Locations and Study Status
21 November 8, 2011 Contacts/Locations and Study Status
22 November 9, 2011 Contacts/Locations and Study Status
23 November 18, 2011 Contacts/Locations and Study Status
24 January 23, 2012 Study Status and Contacts/Locations
25 April 20, 2012 Contacts/Locations and Study Status
26 January 19, 2013 Study Status, Contacts/Locations and Conditions
27 January 24, 2013 Study Status
28 April 23, 2013 Study Status
29 February 1, 2014 Contacts/Locations and Study Status
30 March 28, 2014 Study Status and Contacts/Locations
31 March 30, 2014 Contacts/Locations and Study Status
32 May 21, 2014 Study Status and Contacts/Locations
33 August 13, 2014 Contacts/Locations and Study Status
34 September 24, 2014 Study Status and Contacts/Locations
35 February 2, 2015 Contacts/Locations and Study Status
36 February 23, 2015 Contacts/Locations and Study Status
37 August 17, 2015 Contacts/Locations and Study Status
38 November 1, 2015 Contacts/Locations and Study Status
39 January 26, 2016 Study Status
40 February 2, 2016 Study Status and Contacts/Locations
41 February 17, 2016 Study Status
42 August 11, 2016 Study Status
43 July 26, 2017 Contacts/Locations, Study Status, IPDSharing and Outcome Measures
44 July 27, 2017 Contacts/Locations and Study Status
45 December 6, 2017
Recruitment Status
, Contacts/Locations, Study Status and Study Design
46 November 5, 2018 Study Status and Study Design
47 February 26, 2019
Recruitment Status
, Arms and Interventions and Study Status
48 March 1, 2019 Study Status
49 March 4, 2019 Study Status
50 September 28, 2019 Study Status
Comparison Format:

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Changes (Merged) for Study: NCT01265849
March 4, 2019 (v49) -- September 28, 2019 (v50)

Changes in: Study Status

Study Identification
Unique Protocol ID: CS001P3
Brief Title: Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity (IT-MATTERS)
Official Title: Phase III Study of LI [Multikine®] Plus SOC (Surgery + Radiotherapy or Surgery + Concurrent Radiochemotherapy) in Subjects With Advanced Primary Squamous Cell Carcinoma of the Oral Cavity/Soft Palate vs. SOC Only
Secondary IDs: 2010-019952-35 [EudraCT Number]
Study Status
Record Verification: March 2019 September 2019
Overall Status: Active, not recruiting
Study Start: December 2010
Primary Completion: September December 2019 [Anticipated]
Study Completion: September December 2019 [Anticipated]
First Submitted: December 22, 2010
First Submitted that
Met QC Criteria:
December 22, 2010
First Posted: December 23, 2010 [Estimate]
Last Update Submitted that
Met QC Criteria:
March 4, 2019 September 28, 2019
Last Update Posted: March 5 October 1, 2019 [Actual]
Sponsor/Collaborators
Sponsor: CEL-SCI Corporation
Responsible Party: Sponsor
Collaborators: Teva Pharmaceutical Industries
Orient Europharma Co., Ltd.
Oversight
U.S. FDA-regulated Drug:
U.S. FDA-regulated Device:
Data Monitoring: Yes
Study Description
Brief Summary: The purpose of this study is to determine whether LI administered in combination with cyclophosphamide, indomethacin and zinc (CIZ) in a multivitamin combination prior to standard of care therapy (surgery followed by radiotherapy or concurrent radiochemotherapy) is safe and will increase the overall survival of subjects with previously untreated squamous cell carcinoma of the oral cavity or soft palate at a median of 3 years
Detailed Description:

Head and neck carcinomas constitute about 5% of all cancers annually worldwide. In the US there are about 37,000 new cases annually. Ninety percent are advanced primary squamous cell carcinoma (SCCHN). Approximately 2/3 of SCCHN patients present on their first visit with locally advanced disease. The median 3 year overall survival(OS) for these patients with existing standard of care (SOC) therapies - surgery followed by radiotherapy or combined radiochemotherapy - is between 52 and 55%; the 5 year OS is 43%. There are clearly a large number of SCCHN patients not well served by available modalities.

Regional intra or perilymphatic and/or intratumoral or peritumoral low dose cytokine therapy may have important therapeutic effects in SCCHN patients and constitute an additional anti-tumor mechanism of action different and distinct from current SOC. Leukocyte Interleukin Injection (LI) [Multikine]contains a defined mixture of naturally derived cytokines and chemokines with demonstrated safety and immunomodulatory activity in animals and in man in Phase 1 and 2 clinical trials. LI was administered prior to SOC and in combination with low non-chemotherapeutic doses of cyclophosphamide, indomethacin, and zinc (CIZ) in studies with LI. The results of these studies indicate that the local/regional injection of mixed interleukins (LI) with CIZ prior to SOC can overcome local immunosuppression, break tumor tolerance to tumor antigens and allow for a sustainable and effective anti-tumor immune response.

LI is being tested in this large, global, multinational Phase III clinical trial to develop definitive proof of its efficacy and safety in treating SCCHN. The trial is an open-label randomized multi-center controlled study of LI + CIZ + SOC in subjects with advanced primary SCCHN of the oral cavity/soft palate vs. SOC [The Comparator Arms for, Overall Survival, the Primary End Point of this Study].

Conditions
Conditions: Squamous Cell Carcinoma of the Oral Cavity
Squamous Cell Carcinoma of the Soft Palate
Keywords:
Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model: Parallel Assignment
Number of Arms: 3
Masking: None (Open Label)
Allocation: Randomized
Enrollment: 928 [Actual]
Arms and Interventions
Arms Assigned Interventions
Experimental: LI + CIZ + SOC
LI plus CIZ (cyclophosphamide, indomethacin and zinc) is given as adjuvant therapy prior to standard of care (SOC).
Biological: LI
LI 400IU (2.0mL total daily) 1.0 mL peritumoral, 1.0 mL perilymphatic 5x weekly x3 weeks administered in combination with cyclophosphamide indomethacin and zinc (CIZ) as adjuvant therapy prior to SOC, (surgery followed by radiation or concurrent radiochemotherapy with cisplatin 100mg/m^2 intravenously) to determine if LI plus CIZ affects the overall survival of subjects at median 3 years.

Other Names:
  • Multikine
  • Leukocyte interleukin, injection
Drug: Cyclophosphamide
Cyclophoshamidie is administered IV bolus at a dose of 300mg/m^2 three days prior to beginning treatment with LI. Standard of care (SOC) for previously untreated squamous cell carcinoma of the head and neck is currently surgery followed by radiotherapy (60-70Gy in 30 to 35 fractions over 6 to 7 weeks) or for higher risk subjects (subjects determined at surgery to have positive surgical margins, 2 or more clinically positive nodes or extracapsular nodal spread) radiotherapy is combined with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy
Drug: Indomethacin
One 25mg capsule of indomethacin is administered orally beginning on day one of LI treatment daily until the day before surgery. for LI is administered 400 IU (2.0mL) 1/2 peritumorally and 1/2 perilymphatically 5 times a week for three weeks prior to SOC to determine the contribution of CIZ on LI activity.
Dietary Supplement: Zinc
One capsule daily beginning on day one of treatment with LI until one day before surgery
Procedure: Surgery
Surgery to remove tumor
Drug: Cisplatin
Cisplatin is administered 100mg/m^2 IV is administered with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy i
Radiation: Radiotherapy
60 to 70Gy in 30 to 35 fractions over 6 to 7 weeks. In subjects determined at surgery to have positive surgical margins, 2 or more clinically positive nodes or extracapsular nodal spread radiotherapy is combined with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy
Active Comparator: Standard of Care (SOC)
SOC for previously untreated SCCHN patients is currently surgery followed by either radiotherapy or combined radiochemotherapy depending the patient's risk status for relapse determined at surgery.
Procedure: Surgery
Surgery to remove tumor
Drug: Cisplatin
Cisplatin is administered 100mg/m^2 IV is administered with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy i
Radiation: Radiotherapy
60 to 70Gy in 30 to 35 fractions over 6 to 7 weeks. In subjects determined at surgery to have positive surgical margins, 2 or more clinically positive nodes or extracapsular nodal spread radiotherapy is combined with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy
Experimental: LI + SOC
LI is administered without CIZ to determine the contribution of CIZ to the effects of LI.
Biological: LI
LI 400IU (2.0mL total daily) 1.0 mL peritumoral, 1.0 mL perilymphatic 5x weekly x3 weeks administered in combination with cyclophosphamide indomethacin and zinc (CIZ) as adjuvant therapy prior to SOC, (surgery followed by radiation or concurrent radiochemotherapy with cisplatin 100mg/m^2 intravenously) to determine if LI plus CIZ affects the overall survival of subjects at median 3 years.

Other Names:
  • Multikine
  • Leukocyte interleukin, injection
Procedure: Surgery
Surgery to remove tumor
Drug: Cisplatin
Cisplatin is administered 100mg/m^2 IV is administered with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy i
Radiation: Radiotherapy
60 to 70Gy in 30 to 35 fractions over 6 to 7 weeks. In subjects determined at surgery to have positive surgical margins, 2 or more clinically positive nodes or extracapsular nodal spread radiotherapy is combined with concurrent chemotherapy (cisplatin 100mg/m2 intravenously 1x weekly for 3 weeks on day 1 of weeks 1, 4 and 7 of radiotherapy
Outcome Measures
Primary Outcome Measures:
1. Overall Survival (OS) in LI + CIZ + SOC vs. SOC
OS will be assessed using Kaplan-Meier life-table and compared using a logrank test and confirmed further with tumor stage location and geographic stratified log rank tests. The unstratified logrank test constitutes the primary analysis. A two-sided p-value of 0.05 or less will be considered statistically significant for comparing the two groups. Interim analyses will be performed throughout the study to assess safety, sample size and futility.

[Time Frame: 3 year]
Secondary Outcome Measures:
2. Local regional control (LRC) in LI + CIZ + SOC vs. SOC
LRC is assessed by classifying the first evidence of progression in local and distal sites for the control groups and for the LI treated group. LRC failure includes progression of tumor(s) and nodes or appearance of new disease above the clavicle (but not distant metastases) the reappearance of tumor in the original tumor bed, development of cervical node metastases and new disease above the clavicle other than distant metastases not present at baseline. The total number and corresponding percent of subjects in each of the treated and untreated control groups as well as the time to LRC in days for each group will also be displayed for each group.

[Time Frame: 2 years]
3. Progression Free Survival (PFS) in LI + CIZ + SOC vs.SOC
PFS will be assessed using Kaplan-Meier life-table and compared using a logrank test and confirmed further with stage location and geographic stratified log rank tests. The unstratified logrank test constitutes the primary analysis.A two sided p-value of 0.05 or less will be considered statistically significant in comparing the groups. The Holm closed-sequential procedure will be used to control type 1 error probability to at most 0.05

[Time Frame: 3 year.]
4. Quality of Life (QOL) in LI + CIZ + SOC vs. SOC
QOL will be based on the EORTC QLOQ-C30 and EORTC QLQ-H&N35. QOL data will be assessed for change in QOL from baseline within and between treatment groups.Between group comparisons will be performed using ANOVA or Wilcoxon rank sum test. Within treatment group change from baseline will be performed using a paired t-test or a signed rank test. Two-sided t-test will be used with no adjustment for type I error. An exact binomial test of each treatment group will be used to assess a 10 point improvement between treatments. A Fisher Exact Test will be used for between group comparisons.

[Time Frame: 3 yr.]
Eligibility
Minimum Age: 18 Years
Maximum Age:
Sex: All
Gender Based:
Accepts Healthy Volunteers: No
Criteria:

Inclusion Criteria:

  • Untreated SCCHN of oral cavity/soft palate, categories T1N1-2M0,T2N1-2M0,T3N0-2M0,T4N0-2M0 (T4 allowed only if invasion of mandible is negligible) scheduled for SOC
  • Primary tumor and any positive node(s)measurable in 2 dimensions
  • normal immune function
  • no immunosuppressives with 1 year
  • KPS>70
  • Age>18
  • Male or Female (non-pregnant)
  • Life expectancy >6mo.
  • Able to take oral medication
  • Able to provide informed consent

Exclusion Criteria:

  • Subjects to be treated with other than SOC
  • Tumor invasion of bone (also see inclusion criteria)
  • Tumor classifications T1N0, T2N0, T4N3, any TN classification with M1
  • Tumors in locations other than those specified in inclusion criteria
  • Active peptic ulcer
  • Prior resection of jugular nodes ipsilateral to tumor
  • Acute or chronic viral, bacterial immune or other disease associated with abnormal immune function
  • Subjects on hemodialysis or peritoneal dialysis
  • History of asthma
  • Any condition that in the opinion of the investigator would cause the subject to be unable to participate or tolerate the protocol regimen
Contacts/Locations
Study Officials: Eyal Talor, PhD
Study Director
CEL-SCI Corporation
Locations: United States, Illinois
Simmons Cancer Institute at Southern Illinois University
Springfield, Illinois, United States, 62794
United States, Michigan
Henry Ford Health System Henry Ford Hospital
Detroit, Michigan, United States, 48202
United States, Ohio
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
United States, South Carolina
Medical College Of South Carolina MSC550
Charleston, South Carolina, United States, 29435
United States, Washington
VA Puget Sound Healthcare System & University of WA
Seattle, Washington, United States, 98108
Austria
HNO-Klinik der medizinischen Universitat Graz
Graz, Austria, 8036
Belarus, Minsk
N.N. Alexandrov Research Istitute of Oncology and Medical Radiology
Lesnoy 2, Minsk, Belarus, 223040
Belarus
Vitebsk Regional Oncology Dispensary
Vitebsk, Belarus, 210603
Bosnia and Herzegovina, Tuzla
University Clinical Centre Tuzla
Trnovac, Tuzla, Bosnia and Herzegovina, 75 000
Bosnia and Herzegovina
Clinical Center Banja Luka
Banja Luka, Bosnia and Herzegovina, 78 000
University Clinical Hospital Mostar
Mostar, Bosnia and Herzegovina, 88000
Clinical Centre University of Sarejevo Clinic for ENT
Sarajevo, Bosnia and Herzegovina, 71000
Canada, Ontario
St. Josephs Healthcare Department of Surgery
Hamilton, Ontario, Canada, L8N4A6
Canada, Quebec
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada, JiH 5N4
Canada
CHU de Quebec - L'Hotel Dieu de Quebec
Quebec, Canada, G1R2J6
Croatia
CHC Osijek
Osijek, Croatia, 31000
General Hospital Dr. Josip Bencevic
Slavonski Brod, Croatia, 35000
CH Dubrava
Zagreb, Croatia, 10000
Clinical Hospital Center Zagreb Kispaticeva 12
Zagreb, Croatia, 10000
KBC Sestre Milosrdnice
Zagreb, Croatia, 10000
KBC Zagreb
Zagreb, Croatia, 10000
France
ICL 6 avenue Bourgogne CS30519
Vandoeuvre les Nancy, France, 54519
Hungary, Hajdu Bihar
University of Debrecen Medical and Health Scioence Centre
Debrecen, Hajdu Bihar, Hungary, krt. 98
Hungary, Rath Gyorgy
National institute of Oncology
Budapest, Rath Gyorgy, Hungary, H-1122
Hungary
Semmelweis University
Budapest, Hungary, 1085
University of Pecs Institute of Oncotherapy
Pecs, Hungary, 7628
University of Szeged Dept of Oral and Maxillofacial Surgery
Szeged, Hungary, 6725
Markusovsky Teaching Hospital
Szombathely, Hungary, 9700
India, Andhra Pradesh
Bibi General Hospital and Cancer Centre
Malkapet, Andhra Pradesh, India, 500024
India, Kerala
Amrita Institute of Medical Sciences
Kochi, Kerala, India, 682041
India, Maharashtra
Sujan Regional Cancer Hospital & Amravati Cancer Foundation
Amravati, Maharashtra, India, 444606
Government Medical College and Hospital
Aurangabad, Maharashtra, India, 431001
Tata Memorial Hospital
Mumbai, Maharashtra, India, 400012
India, Naka Nashik
Curie Manavata Cancer Center
Mumbai, Naka Nashik, India, 422004
India, Rajashlan
Searoc Cancer Center
Jaipur, Rajashlan, India, 302013
India, Tamil Nadu
V.N. Cancer Center G. Kuppuswamy Naidu Memorial Hospital
Coimbatore, Tamil Nadu, India, 641037
Meenakshi Mission Hospital and Research Centre
Madurai, Tamil Nadu, India, 625107
India, Thiruvananthapuram
Regional Cancer Center
Kerola, Thiruvananthapuram, India, 695011
India, Uttar Pradesh
Galaxy Cancer Center
Ghaziabad, Uttar Pradesh, India, 210010
Israel, Saint Haifa
Rambam Health Care Campus
Sha`ar Ha`Aliya, Saint Haifa, Israel, 31906
Israel, Tikva
Rabin Medical Center
Petaẖ Tiqwa, Tikva, Israel, 49100
Italy
National Tumor Institute of Italy
Naples, Italy, 80131
Ospedale S.G. Moscati Santissima Annunziata
Taranto, Italy, 74010
Malaysia, Penang
Dept of Head and Neck Surgery School of Medical Sciences Univ. Sains
Kuantan, Penang, Malaysia, 16150
Malaysia
University Kabangsan Medical Center
Kuala Lumpur, Malaysia, 56000
Poland, Ul Paderewskiego 4
Wojewodzki Szpital Specjalistyczny im Kopernika
Lodz, Ul Paderewskiego 4, Poland, 93-509
Poland, Ul. Artwinskiego 3
Swietokrzyskie Centrum Onkologii
Kielce, Ul. Artwinskiego 3, Poland, 25-734
Poland, Ul. Roentgena 5
Centrum Onkologii im. Prof. Lukaszcyka
Warsaw, Ul. Roentgena 5, Poland, 02-781
Centrum Onkologi-Instytut im. Marie Sklodowskiej-Curie
Warszawa, Ul. Roentgena 5, Poland, 02-781
Poland
ul. M. Sklodowskiej-Curie 24A
Bialystok, Poland, 15-276
Szpital Specialistyczny im. Ludwika Rydgiera
Krakow, Poland, 31826
Samodzielny Publiczny Szpital Kliniczny Klinika Otolarryngologii I Onkologii Laryngologicznej
Lublin, Poland, 20-954
Weilkopolskie Centrum Onkologii Klinika Chirurgii Glowy Szye Onkologii Laryngologiczne
Poznan, Poland, 61-866
Uniwersitecki Szpital Kliniczny Klinika Otolaryngologii Chirugii Glowy i Szxyi
Wroclaw, Poland, 50-556
Romania
Regional Institute of Oncology IASI
Iasi, Romania, 700483
Spital Clinic Judetean Mures
Targu Mures, Romania, 540072
Russian Federation, Ekaterinberg
Sverdlovsk Regional Cancer Center
Sverdlov, Ekaterinberg, Russian Federation, 620905
Russian Federation, Leningradskaya
Leningrad Regional Oncology Center
St. Petersburg, Leningradskaya, Russian Federation, 188663
Russian Federation
Kursk Regional Clinical Oncology Dispensary
Kursk, Russian Federation, 305035
Blokhin Cancer Research Center
Moscow, Russian Federation, 115478
N.N. Blokhin Russian Cancer Research Center
Moscow, Russian Federation, 115478
Budget Institution of Healthcare of Omsk Region Clincal Oncology Dispensary
Omsk, Russian Federation, 644013
Ryazan Clinical oncology Dispensary
Ryazan, Russian Federation, 39011
Serbia, Pasterova 14
Serbia Clinic for ENT and Maxillofacial Surgery
Belgrade, Pasterova 14, Serbia, 11000
Serbia
Clincal Center Serbia Clinic for Oral and Maxillofacial Surgery
Belgrade, Serbia, 11000
Faculty of Dental Medicine Clinic for Maxillofacial Surgery
Belgrade, Serbia, 11000
Military Medical Academy Clinic for Maxillofacial Surgery
Belgrade, Serbia, 11000
Clinical Center Nis center for Oncology
Nis, Serbia, 18 000
Clinic for Stomatology department for maxillofacial Surgery
Nis, Serbia, 18000
Clinical center Vojvodina Clinic for ORL
Novi Sad, Serbia, 21000
Clinical Centre Vojvodina Clinic for Maxillofacial Surgery
Novi Sad, Serbia, 21000
Spain
hospiatl Universitari Vall d'Hebron
Barcelona, Spain, 08035
Hospital Universitario de Princesa
Madrid, Spain, 28006
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Complejo Hospitalario Univ. de Santiago
Santiago de Compostela, Spain, 15706
Consorsio Hospital General Universitario de valencia
Valencia, Spain, 46014
Sri Lanka
National Cancer Institute Dept of Clinical Oncology & Radiotherapy
Colombo, Sri Lanka, 10280
Oncology Unit Teaching Hospital Karapitya
Galle, Sri Lanka
Taiwan, Kaohsiung
Kaohsiung Branch Chang Gung Memorial Hospital
Niaosong, Kaohsiung, Taiwan, 833
Taiwan, Tainan
National Cheng Kung University Hospital
Taipei, Tainan, Taiwan, 704
Taiwan, Taipei
National Taiwan Research Hospital
Chengshan, Taipei, Taiwan, 100
Taiwan, Taoyuan
Linkou Branch Chang Gung Memorial Hospital
Guishan, Taoyuan, Taiwan, 333
Taiwan
Changua Christian Hospital
Chang-hua, Taiwan, 500
Buddhist Tzu Chi General Hospital, Hualien Branch
Hualien City, Taiwan, 970
China Medical University Hospital
Taichung, Taiwan, 404
Taichung Veterans General Hospital
Taichung, Taiwan, 40705
Shin-Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan, 111
Thailand
Khon Kaen University Dept of Otolaryngology
Nai- Muang, Thailand, 40002
Turkey
Haceteppe University Dept of Otolaryngology - Head and Neck Surgery
Ankara, Turkey, 06100
Acibadem University Maslak Hospital ENT Department
Istanbul, Turkey
Ukraine
Cherkasky Regional Oncological Dyspensary Dept. Head and Neck tumour
Cherkasy, Ukraine, 18009
Clinical Diagnostic Laboratory of Dnepropetrovsk Municipal Institution City Multidisciplinary Clinical Hospital No. 4
Dnepropetrovsk, Ukraine, 49102
Donetsk Regional Antitumor Center
Donetsk, Ukraine, 83092
Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine Dept. of Remote, Combined Radiation and Complex Therapy
Kharkiv, Ukraine, 61024
Kharkiv Regional Clinical Oncology Center Dept. Of Head and Neck Tumour
Kharkiv, Ukraine
Kiev City Clinical Oncology Center of the Main Health Care Dept of Kiev Day Hospital Radiotherapy Dept.
Kiev, Ukraine
Kiev City Clinical Oncology Center of the Main Health Care Dept. of the Kiev Day Hospital
Kiev, Ukraine
LVIV State OncologyRegional treatment and Diagnostic Ceneter
Lviv, Ukraine, 79031
Sumy Regional Clinical Oncology Dyspensary
Sumy, Ukraine, 40004
Zaporiz'ka Regional Clinical Oncology Dispensary
Zaporiz'ka Oblast', Ukraine, 69040
United Kingdom
Aintree University Hospital
Liverpool, United Kingdom, L9 7AL
IPDSharing
Plan to Share IPD: No
There is no plan
References
Citations:
Links:
Available IPD/Information:

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