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History of Changes for Study: NCT00002708
Radiation Therapy With or Without Radiosurgery in Treating Patients With Brain Metastases
Latest version (submitted November 18, 2013) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 June 23, 2005 None (earliest Version on record)
2 January 11, 2007 Contacts/Locations and Study Status
3 February 20, 2007 Sponsor/Collaborators, References, Eligibility, Contacts/Locations, Arms and Interventions, Conditions, Study Status, Study Design, Study Description and Study Identification
4 May 16, 2007 Study Status and Study Design
5 October 26, 2007 Arms and Interventions and Study Status
6 November 16, 2007 Study Status
7 December 15, 2007 Study Status
8 February 26, 2008 References and Study Status
9 March 1, 2008 Study Status
10 March 5, 2008 Recruitment Status and Study Status
11 July 23, 2008 Study Design and Study Status
12 February 6, 2009 Arms and Interventions and Study Status
13 August 29, 2009 Conditions and Study Status
14 November 18, 2013 Study Identification, Study Design, Study Status, Arms and Interventions, Oversight and Sponsor/Collaborators
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Study NCT00002708
Submitted Date:  June 23, 2005 (v1)

Open or close this module Study Identification
Unique Protocol ID: CDR0000064522
Brief Title: Radiation Therapy With or Without Radiosurgery in Treating Patients With Brain Metastases
Official Title: Phase III Randomized Study of Fractionated External Beam Whole Brain Radiotherapy With Versus Without a Stereotactic Radiosurgery Boost in Patients With One Unresected Brain Metastasis
Secondary IDs: RTOG-9508
Open or close this module Study Status
Record Verification: April 2004
Overall Status: Active, not recruiting
Study Start: January 1996
Primary Completion:
Study Completion:
First Submitted: November 1, 1999
First Submitted that
Met QC Criteria:
April 12, 2004
First Posted: April 13, 2004 [Estimate]
Last Update Submitted that
Met QC Criteria:
June 23, 2005
Last Update Posted: June 24, 2005 [Estimate]
Open or close this module Sponsor/Collaborators
Sponsor: National Cancer Institute (NCI)
Responsible Party:
Collaborators: Radiation Therapy Oncology Group
Open or close this module Oversight
U.S. FDA-regulated Drug:
U.S. FDA-regulated Device:
Data Monitoring:
Open or close this module Study Description
Brief Summary:

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether giving radiation therapy during surgery is more effective than standard radiation therapy in treating brain metastases.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without radiosurgery in treating patients with brain metastases that cannot be removed during surgery.

Detailed Description:

OBJECTIVES: I. Compare the overall survival of patients with one unresected brain metastasis treated with conventional whole brain radiotherapy (WBRT) with vs. without a stereotactic radiosurgery (SRS) boost.

II. Compare sites of recurrence and cause of death in these patients treated with WBRT followed by SRS vs. WBRT alone.

PROTOCOL OUTLINE: This is a randomized, multicenter study. Patients are stratified according to center and extracranial disease (yes or no). Patients are randomized to one of two treatment arms.

Arm I: Patients receive fractionated external beam whole brain irradiation (WBRT) 5 days each week for 3 weeks. Both portals are treated during each radiotherapy session. Patients who still have a solitary lesion with a diameter no greater than 4.0 cm also receive stereotactic radiosurgery within 7 days of completing WBRT.

Arm II: Patients receive WBRT only. Patients are followed every 3 months for 1 year, then every 4 months for 2 years, and then annually.

PROJECTED ACCRUAL:

A total of 262 patients will be accrued over 2.5-3.75 years for this study. The study may close early if interim analysis after 33% and 67% of patients have been followed for 6 months produces significant results. After 6/14/99 an additional 46 patients with a solitary brain metastasis only will be accrued.

Open or close this module Conditions
Conditions: Brain Metastases
Keywords: adult solid tumor
body system/site cancer
brain metastases
cancer
metastatic cancer
site, metastatic cancer
solid tumor
unclassified/other cancer
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Treatment
Study Phase: Phase 3
Interventional Study Model:
Number of Arms:
Masking: (masked roles unspecified)
Enrollment:
Open or close this module Arms and Interventions
Intervention Details:
Procedure: Radiation therapy
Procedure: Radiosurgery
Open or close this module Outcome Measures
Open or close this module Eligibility
Minimum Age: 18 Years
Maximum Age:
Sex:
Gender Based:
Accepts Healthy Volunteers:
Criteria:

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

  • No more than 1 unresected or subtotally resected brain metastasis lesion from histologically confirmed systemic malignancy
  • Eligible only if surgical resection refused by patient or resection deemed inappropriate by patient's physician
  • 1 intraparenchymal metastasis clearly defined on contrast enhanced MRI
  • Maximum diameter of lesion no greater than 4.0 cm
  • No leukemia or lymphoma
  • Extracranial sites of primary metastatic disease allowed if no clinical or radiographic evidence of progression within 1 month prior to entry
  • No metastasis to brainstem, midbrain, pons, or medulla
  • No leptomeningeal metastasis by MRI or CSF evaluation
  • No metastasis within 10 mm of optic nerves and chiasm (area must be excluded from high dose stereotactic radiosurgery boost field)

--Prior/Concurrent Therapy--

  • Biologic therapy: Not specified
  • Chemotherapy: No concurrent chemotherapy for systemic cancer
  • Endocrine therapy: Concurrent hormonal therapy, including tamoxifen, allowed
  • Radiotherapy: No prior cranial radiotherapy
  • Surgery: Prior subtotal resection allowed
  • Other: No other concurrent treatment for brain metastasis until recurrence

--Patient Characteristics--

  • Age: 18 and over
  • Performance status: 70-100% Karnofsky
  • Hematopoietic: Absolute neutrophil count at least 1,000/mm3; Platelet count at least 50,000/mm3; Hemoglobin at least 8 g/dL
  • Hepatic: Not specified
  • Renal: Not specified
  • Other: Neurologic status 0-2; No major medical or psychiatric contraindication to protocol entry; Fertile patients must use effective contraception
Open or close this module Contacts/Locations
Study Officials: David W. Andrews
Study Chair
Radiation Therapy Oncology Group
Locations: United States, Alabama
University of Alabama Comprehensive Cancer Center
Birmingham, Alabama, United States, 35294
Comprehensive Cancer Institute of Huntsville
Huntsville, Alabama, United States, 35801
Huntsville Hospital System
Huntsville, Alabama, United States, 35801
Mobile Infirmary Medical Center
Mobile, Alabama, United States, 36640-0460
Urology Associates - Mobile AL
Mobile, Alabama, United States, 36640
MBCCOP - Gulf Coast
Mobile, Alabama, United States, 36652
Alabama Oncology, LLC
Montgomery, Alabama, United States, 36106-2801
Radiation Oncology Associates of West Alabama
Tuscallosa, Alabama, United States, 35401
United States, Alaska
Providence Cancer Therapy Center
Anchorage, Alaska, United States, 99508
United States, Arizona
Arizona Cancer Center
Tucson, Arizona, United States, 85724
United States, California
Mount Diablo Medical Center
Concord, California, United States, 94524-4110
California Cancer Center
Fresno, California, United States, 93720
Saint Agnes Cancer Center
Fresno, California, United States, 93720
Glendale Memorial Hospital and Health Center
Glendale, California, United States, 91204
Sutter Health Western Division Cancer Research Group
Greenbrae, California, United States, 94904
University of California San Diego Cancer Center
La Jolla, California, United States, 92093-0658
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Veterans Affairs Medical Center - Long Beach
Long Beach, California, United States, 90822
Kaiser Permanente Medical Center - Los Angeles
Los Angeles, California, United States, 90027
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033-0800
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, United States, 90095-1781
Beckman Research Institute, City of Hope
Los Angeles, California, United States, 91010
CCOP - Bay Area Tumor Institute
Oakland, California, United States, 94609-3305
Cancer Care Center
Pomona, California, United States, 91767
Radiation Oncology Center - Sacramento
Sacramento, California, United States, 95816
Radiation Medical Group, Inc.
San Diego, California, United States, 92101-1492
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, United States, 94115-0128
O'Connor Hospital
San Jose, California, United States, 95128
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, United States, 95403
Stanford University
Stanford, California, United States, 94305
United States, Colorado
Memorial Hospital Cancer Center
Colorado Springs, Colorado, United States, 80909
University of Colorado Cancer Center
Denver, Colorado, United States, 80262
United States, Connecticut
Bridgeport Hospital
Bridgeport, Connecticut, United States, 06610
Whittingham Cancer Center
Norwalk, Connecticut, United States, 06856
United States, Delaware
CCOP - Christiana Care Health Services
Wilmington, Delaware, United States, 19899
United States, District of Columbia
Walter Reed Army Medical Center
Washington, District of Columbia, United States, 20307-5000
United States, Florida
Lykes Center for Radiation Therapy
Clearwater, Florida, United States, 33757-0210
Halifax Medical Center
Daytona Beach, Florida, United States, 32114
Radiation Therapy Associates - Fort Myers
Fort Myers, Florida, United States, 33901
University of Florida Health Science Center
Gainesville, Florida, United States, 32610-0296
Health First Holmes Regional Medical Center
Melbourne, Florida, United States, 32901
Veterans Affairs Medical Center - Miami
Miami, Florida, United States, 33125
Sylvester Cancer Center, University of Miami
Miami, Florida, United States, 33136
Baptist Hospital of Miami
Miami, Florida, United States, 33176-2197
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
Florida Radiation Oncology Group
Orange Park, Florida, United States, 32073
MD Anderson Cancer Center Orlando
Orlando, Florida, United States, 32806
Bay Medical Center
Panama City, Florida, United States, 32401
Gulf Coast Cancer Treatment Center
Panama City, Florida, United States, 32405-4587
West Florida Cancer Institute - Pensacola
Pensacola, Florida, United States, 32514
Bayfront Medical Center
Saint Petersburg, Florida, United States, 33701
Sarasota Radiation and Medical Oncology Center
Sarasota, Florida, United States, 34233
Tallahassee Memorial Healthcare
Tallahassee, Florida, United States, 32308
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612
United States, Georgia
Emory University Hospital - Atlanta
Atlanta, Georgia, United States, 30322
CCOP - Atlanta Regional
Atlanta, Georgia, United States, 30342-1701
Medical Center/John B. Amos Community Cancer Center
Columbus, Georgia, United States, 31902
InterCommunity Cancer Center at Rome
Rome, Georgia, United States, 30161
United States, Illinois
Northwest Community Hospital
Arlington Heights, Illinois, United States, 60005
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637
CCOP - Central Illinois
Decatur, Illinois, United States, 62526
Provena St. Joseph Hospital- Regional Cancer Care Center
Elgin, Illinois, United States, 60123
Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Lutheran General Cancer Care Center
Park Ridge, Illinois, United States, 60068
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61636
United States, Indiana
St. John's Medical Center
Anderson, Indiana, United States, 46016
Veterans Affairs Medical Center - Indianapolis (Roudebush)
Indianapolis, Indiana, United States, 46202
Clarion Health Partners Inc.
Indianapolis, Indiana, United States, 46206-1367
Community Hospitals of Indianapolis - Regional Cancer Center
Indianapolis, Indiana, United States, 46219
Ball Memorial Hospital
Muncie, Indiana, United States, 47303-3499
Memorial Hospital of South Bend
South Bend, Indiana, United States, 46601
St. Joseph's Radiation Oncology Center
South Bend, Indiana, United States, 46617
United States, Iowa
Wendt Regional Cancer Center of Finley Hospital
Dubuque, Iowa, United States, 52001
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
United States, Kentucky
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, United States, 40511-1093
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, United States, 40536-0084
James Graham Brown Cancer Center
Louisville, Kentucky, United States, 40202
Louisville Radiation Oncology
Louisville, Kentucky, United States, 40215
Merle M. Mahr Cancer Center
Madisonville, Kentucky, United States, 42431
Western Baptist Hospital
Paducah, Kentucky, United States, 42001
United States, Louisiana
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States, 70809
Romagosa Radiation Oncology Center
Lafayette, Louisiana, United States, 70501
MBCCOP - LSU Medical Center
New Orleans, Louisiana, United States, 70112
Tulane University School of Medicine
New Orleans, Louisiana, United States, 70112
CCOP - Ochsner
New Orleans, Louisiana, United States, 70121
United States, Maine
Maine Medical Center
Portland, Maine, United States, 04102
United States, Maryland
Anne Arundel Oncology Center
Annapolis, Maryland, United States, 21401
Greater Baltimore Medical Center and Cancer Center
Baltimore, Maryland, United States, 21204
Harbor Hospital Center
Baltimore, Maryland, United States, 21225
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21225
Johns Hopkins Oncology Center
Baltimore, Maryland, United States, 21231
Radiation Oncology Affiliates of Maryland, P.A.
Baltimore, Maryland, United States, 21237
Peninsula Regional Medical Center
Salisbury, Maryland, United States, 21801
United States, Massachusetts
Cape Cod Hospital
Hyannis, Massachusetts, United States, 02601
Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain, Massachusetts, United States, 02130
United States, Michigan
CCOP - Ann Arbor Regional
Ann Arbor, Michigan, United States, 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109-0752
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Henry Ford Hospital
Detroit, Michigan, United States, 48202
McLaren Regional Cancer Center
Flint, Michigan, United States, 48432
Hurley Medical Center
Flint, Michigan, United States, 48503
CCOP - Kalamazoo
Kalamazoo, Michigan, United States, 49007-3731
Sparrow Regional Cancer Center
Lansing, Michigan, United States, 48909
Marquette General Hospital
Marquette, Michigan, United States, 49855
MidMichigan Medical Center - Midland
Midland, Michigan, United States, 48670
William Beaumont Hospital
Royal Oak, Michigan, United States, 48073
St. Mary's Medical Center
Saginaw, Michigan, United States, 48601
United States, Minnesota
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
United States, Mississippi
North Mississippi Medical Center/Cancer Center
Tupelo, Mississippi, United States, 38801
United States, Missouri
Ellis Fischel Cancer Center - Columbia
Columbia, Missouri, United States, 65203
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
St. Louis University Health Sciences Center
Saint Louis, Missouri, United States, 63110-0250
Mallinckrodt Institute of Radiology
Saint Louis, Missouri, United States, 63110
Cancer Research for the Ozarks
Springfield, Missouri, United States, 65807
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, United States, 65807
United States, Montana
CCOP - Montana Cancer Consortium
Billings, Montana, United States, 59101
United States, Nebraska
Methodist Cancer Center - Omaha
Omaha, Nebraska, United States, 68114
Nebraska Health System
Omaha, Nebraska, United States, 68198-7400
United States, Nevada
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States, 89106
United States, New Hampshire
Norris Cotton Cancer Center
Lebanon, New Hampshire, United States, 03756
Elliot Regional Cancer Center
Manchester, New Hampshire, United States, 03103
United States, New Jersey
Cooper Cancer Institute
Camden, New Jersey, United States, 08103
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, United States, 07018-1095
John F. Kennedy Medical Center
Edison, New Jersey, United States, 08818
Trinitas Hospital - Jersey Street Campus
Elizabeth, New Jersey, United States, 07201
Monmouth Medical Center
Long Branch, New Jersey, United States, 07740
South Jersey Hospital - Millville
Millville, New Jersey, United States, 08332
Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
Mount Holly, New Jersey, United States, 08060
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08901
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Atlantic City Medical Center
Pomona, New Jersey, United States, 08240
Community Medical Center
Toms River, New Jersey, United States, 08755
St. Francis Medical Center
Trenton, New Jersey, United States, 08629
Associated Radiologists, P.A.
Warren, New Jersey, United States, 07059
United States, New Mexico
Saint Joseph Medical Center
Albuquerque, New Mexico, United States, 87102
United States, New York
Cancer Center of Albany Medical Center
Albany, New York, United States, 12208
Albert Einstein Comprehensive Cancer Center
Bronx, New York, United States, 10461
State University of New York Health Science Center at Brooklyn
Brooklyn, New York, United States, 11203
New York Methodist Hospital
Brooklyn, New York, United States, 11215-3609
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263-0001
Finger Lakes Radiation Oncology, P.C.
Clifton Springs, New York, United States, 14432
CCOP - North Shore University Hospital
Manhasset, New York, United States, 11030
Beth Israel Medical Center
New York, New York, United States, 10003
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, United States, 10016
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Champlain Valley Physicians Hospital Medical Center
Plattsburgh, New York, United States, 12901
Vassar Brothers Hospital
Poughkeepsie, New York, United States, 12601
University of Rochester Cancer Center
Rochester, New York, United States, 14642
New York Medical College
Valhalla, New York, United States, 10595
United States, North Carolina
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, United States, 27599-7295
Northeast Medical Center
Concord, North Carolina, United States, 28025
East Carolina University School of Medicine
Greenville, North Carolina, United States, 27858-4354
Catawba Memorial Hospital
Hickory, North Carolina, United States, 28601
CCOP - Southeast Cancer Control Consortium
Winston Salem, North Carolina, United States, 27104-4241
Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
Winston Salem, North Carolina, United States, 27157-1082
United States, North Dakota
Meritcare Roger Maris Cancer Center
Fargo, North Dakota, United States, 58122
UNIMED Medical Center
Minot, North Dakota, United States, 58701
United States, Ohio
Akron General Medical Center
Akron, Ohio, United States, 44302
Akron City Hospital
Akron, Ohio, United States, 44309
Christ Hospital
Cincinnati, Ohio, United States, 45219
Ireland Cancer Center
Cleveland, Ohio, United States, 44106-5065
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44106
CCOP - Columbus
Columbus, Ohio, United States, 43206
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, United States, 43210
CCOP - Dayton
Kettering, Ohio, United States, 45429
CCOP - Toledo Community Hospital Oncology Program
Toledo, Ohio, United States, 43623-3456
United States, Oklahoma
St. Anthony Hospital
Oklahoma City, Oklahoma, United States, 73101
St. John Medical Center
Tulsa, Oklahoma, United States, 74104
United States, Oregon
CCOP - Columbia River Program
Portland, Oregon, United States, 97213
United States, Pennsylvania
Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18103
St. Luke's Hospital Regional Cancer Center
Bethlehem, Pennsylvania, United States, 18015
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822-2001
Mercy Catholic Medical Center, Mercy Fitzgerald Divison
Darby, Pennsylvania, United States, 19023
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States, 19026
Penn State Geisinger Cancer Center
Hershey, Pennsylvania, United States, 17033
Hahnemann University Hospital
Philadelphia, Pennsylvania, United States, 19102-1192
University of Pennsylvania Cancer Center
Philadelphia, Pennsylvania, United States, 19104
Veterans Affairs Medical Center - Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States, 19107
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States, 19141
University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, United States, 15213
Mercy Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15219
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, United States, 15224
Reading Hospital and Medical Center
Reading, Pennsylvania, United States, 19612-6052
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, United States, 18501
Wilkes Barre General Hospital
Wilkes Barre, Pennsylvania, United States, 18764
CCOP - MainLine Health
Wynnewood, Pennsylvania, United States, 19096
York Hospital
York, Pennsylvania, United States, 17315
United States, Rhode Island
Roger Williams Medical Center/BUSM
Providence, Rhode Island, United States, 02908-4735
United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425-0721
CCOP - Greenville
Greenville, South Carolina, United States, 29615
CCOP - Upstate Carolina
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57709
United States, Tennessee
Jackson-Madison County General Hospital
Jackson, Tennessee, United States, 38301
Baptist Regional Cancer Center - Knoxville
Knoxville, Tennessee, United States, 37901
University of Tennessee, Memphis Cancer Center
Memphis, Tennessee, United States, 38103
CCOP - Baptist Cancer Institute
Memphis, Tennessee, United States, 38117
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States, 37232-6838
United States, Texas
Harrington Cancer Center
Amarillo, Texas, United States, 79106
Julie and Ben Rogers Cancer Institute
Beaumont, Texas, United States, 77701
University of Texas Medical Branch
Galveston, Texas, United States, 77555-0209
University of Texas - MD Anderson Cancer Center
Houston, Texas, United States, 77030-4009
Wilford Hall - 59th Medical Wing
Lackland Air Force Base, Texas, United States, 78236-5300
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, United States, 79410-1894
Bayshore Medical Center
Pasadena, Texas, United States, 77504
East Texas Medical Center - Cancer Institute
Tyler, Texas, United States, 75701
United States, Utah
Dixie Regional Medical Center
Saint George, Utah, United States, 84770
University of Utah Health Sciences Center
Salt Lake City, Utah, United States, 84132
LDS Hospital
Salt Lake City, Utah, United States, 84143
United States, Vermont
CCOP - Southwestern Vermont Regional Cancer Center
Bennington, Vermont, United States, 05201
Vermont Cancer Center
Burlington, Vermont, United States, 05401-3498
Green Mountain Oncology Group
Rutland, Vermont, United States, 05701
United States, Virginia
Martha Jefferson Hospital
Charlottesville, Virginia, United States, 22901
Cancer Center, University of Virginia HSC
Charlottesville, Virginia, United States, 22908
RMH Regional Canter Center
Harrisonburg, Virginia, United States, 22801
Virginia Baptist Hospital
Lynchburg, Virginia, United States, 24503
Naval Medical Center, Portsmouth
Portsmouth, Virginia, United States, 23708-2197
United States, Washington
Swedish Cancer Institute
Seattle, Washington, United States, 98104
Virginia Mason Medical Center
Seattle, Washington, United States, 98111
Deaconess Medical Center
Spokane, Washington, United States, 99210-0248
Yakima Valley Memorial Hospital
Yakima, Washington, United States, 98902
United States, West Virginia
Schiffler Cancer Center
Wheeling, West Virginia, United States, 26003
United States, Wisconsin
St. Vincent Hospital
Green Bay, Wisconsin, United States, 54307-3508
Gundersen Lutheran Medical Foundation
La Crosse, Wisconsin, United States, 54601
Southern Wisconsin Radiotherapy Center
Madison, Wisconsin, United States, 53713
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792
Marshfield Clinic
Marshfield, Wisconsin, United States, 54449
Community Memorial Hospital
Menomonee Falls, Wisconsin, United States, 53051
St. Joseph's Hospital
Milwaukee, Wisconsin, United States, 53210
Columbia Hospital
Milwaukee, Wisconsin, United States, 53211
St. Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Veterans Affairs Medical Center - Milwaukee (Zablocki)
Milwaukee, Wisconsin, United States, 53295
Southeastern Wisconsin Regional Cancer Center
Racine, Wisconsin, United States, 53405
Waukesha Memorial Hospital
Waukesha, Wisconsin, United States, 53188
Canada, Alberta
Tom Baker Cancer Center - Calgary
Calgary, Alberta, Canada, T2N 4N2
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Canada, British Columbia
BC Cancer Agency
Vancouver, British Columbia, Canada, V5Z 4E6
Canada, New Brunswick
Doctor Leon Richard Oncology Centre
Moncton, New Brunswick, Canada, E1C 8X3
Saint John Regional Hospital
Saint John, New Brunswick, Canada, E2L 4L2
Canada, Newfoundland and Labrador
Newfoundland Cancer Treatment and Research Foundation
St. Johns, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Nova Scotia
Nova Scotia Cancer Centre
Halifax, Nova Scotia, Canada, B3H 1V7
Canada, Ontario
Cancer Care Ontario-Hamilton Regional Cancer Centre
Hamilton, Ontario, Canada, L8V 5C2
Kingston Regional Cancer Centre
Kingston, Ontario, Canada, K7L 5P9
Cancer Care Ontario-London Regional Cancer Centre
London, Ontario, Canada, N6A 4L6
Ottawa Regional Cancer Centre - General Campus
Ottawa, Ontario, Canada, K1H 1C4
Northeastern Ontario Regional Cancer Centre, Sudbury
Sudbury, Ontario, Canada, P3E 5J1
Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay, Ontario, Canada, P7A 7T1
Toronto Sunnybrook Regional Cancer Centre
Toronto, Ontario, Canada, M4N 3M5
Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Canada, Quebec
Centre Universitaire de Sante de l'Estrie - Site Fleurimont
Fleurimont, Quebec, Canada, J1H 5N4
McGill University Department of Oncology
Montreal, Quebec, Canada, H2W 1S6
Canada, Saskatchewan
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Open or close this module IPDSharing
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Open or close this module References
Citations: Sperduto P, Scott C, Andrews D, et al.: Preliminary report of RTOG 95-08: a phase III trial comparing whole brain irradiation alone versus whole brain irradiation plus stereotactic radiosurgery for patients with two or three unresected brain metastases. International Journal of Radiation Oncology, Biology, Physics 48: A-6, 113, 2000.
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