Memory Consolidation in Obstructive Sleep Apnea
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|ClinicalTrials.gov Identifier: NCT01800786|
Recruitment Status : Completed
First Posted : February 28, 2013
Results First Posted : June 6, 2017
Last Update Posted : June 6, 2017
The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic marker APOε4 as a modulator, and (ii) that CPAP can reverse some or all of these measured memory deficits.
In addition, we are exploring which aspects of OSA (e.g., changes in sleep architecture, measures of hypoxemia, or the EEG power spectrum) most likely impact sleep-dependent memory processing.To this end, we are using specific cognitive tasks for which sleep-dependent memory consolidation processes have previously been demonstrated by our group and others. In addition, we are carrying out quantitative EEG power spectral analyses, to delineate abnormal functioning of brain regions with more precision.
|Condition or disease||Intervention/treatment|
|Obstructive Sleep Apnea||Device: CPAP|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||33 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Memory Consolidation in Obstructive Sleep Apnea|
|Actual Study Start Date :||August 2011|
|Primary Completion Date :||December 2015|
|Study Completion Date :||June 30, 2016|
Active Comparator: OSA-CPAP group
OSA patient will use CPAP for 3 months
No Intervention: OSA -no CPAP
newly diagnosed OSA patient will not wear CPAP for 3 months
- Overnight Change in Declarative Memory Performance [ Time Frame: 3 months ]
At 3 months, we compared average overnight changes between evening and morning performance on a declarative memory test between untreated OSA subjects and those who received CPAP therapy for 3 months.
Positive numbers represent an increase in performance.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01800786
|United States, Massachusetts|
|Brigham and Women's Hospital|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Ina Djonlagic, MD||Brigham and Women's Hospital|