Memory Consolidation in Obstructive Sleep Apnea
The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic marker APOε4 as a modulator, and (ii) that CPAP can reverse some or all of these measured memory deficits.
In addition, we are exploring which aspects of OSA (e.g., changes in sleep architecture, measures of hypoxemia, or the EEG power spectrum) most likely impact sleep-dependent memory processing.To this end, we are using specific cognitive tasks for which sleep-dependent memory consolidation processes have previously been demonstrated by our group and others. In addition, we are carrying out quantitative EEG power spectral analyses, to delineate abnormal functioning of brain regions with more precision.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
|Official Title:||Memory Consolidation in Obstructive Sleep Apnea|
- Overnight Change in Declarative Memory Performance [ Time Frame: 3 months ]
At 3 months, we compared average overnight changes between evening and morning performance on a declarative memory test between untreated OSA subjects and those who received CPAP therapy for 3 months.
Positive numbers represent an increase in performance.
|Actual Study Start Date:||August 2011|
|Study Completion Date:||June 30, 2016|
|Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Active Comparator: OSA-CPAP group
OSA patient will use CPAP for 3 months
No Intervention: OSA -no CPAP
newly diagnosed OSA patient will not wear CPAP for 3 months
Please refer to this study by its ClinicalTrials.gov identifier: NCT01800786
|United States, Massachusetts|
|Brigham and Women's Hospital|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Ina Djonlagic, MD||Brigham and Women's Hospital|