Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Neural Changes in the Aging Auditory System

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00264407
Recruitment Status : Completed
First Posted : December 12, 2005
Last Update Posted : December 12, 2005
Sponsor:
Collaborators:
Rochester Institute of Technology
National Institute on Aging (NIA)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by:
University of Rochester

Brief Summary:
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.

Condition or disease Intervention/treatment
Progesterone Estrogens Hearing Psychoacoustics Auditory Perceptual Disorders Drug: Hormone Replacement Therapy - HRT

Detailed Description:

Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT.

Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons.

.

Layout table for study information
Study Type : Observational
Enrollment : 126 participants
Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Age-Related Hearing Loss: Presbycusis & Its Neural Bases
Study Start Date : January 2001
Study Completion Date : February 2005

Resource links provided by the National Library of Medicine






Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   60 Years to 86 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy middle ears

Exclusion Criteria:

  • ototoxic medications
  • serious medical health problems
  • neurological conditions
  • Meniere’s disease or labyrinthitis
  • those who failed cognitive screening tests (Mini-Mental Test)
  • current/heavy smokers
  • conductive hearing loss
  • history of noise damage and/or audiograms signifying noise damage
  • poor speech discrimination scores (80% or less)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00264407


Locations
Layout table for location information
United States, New York
International Center Hearing & Speech Research - NTID - RIT
Rochester, New York, United States, 14623-5604
University of Rochester Medical Center
Rochester, New York, United States, 14642
Sponsors and Collaborators
University of Rochester
Rochester Institute of Technology
National Institute on Aging (NIA)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
Layout table for investigator information
Study Director: Robert D Frisina, Ph.D. University of Rochester Medical School
Layout table for additonal information
ClinicalTrials.gov Identifier: NCT00264407    
Other Study ID Numbers: 10121
P01AG009524 ( U.S. NIH Grant/Contract )
First Posted: December 12, 2005    Key Record Dates
Last Update Posted: December 12, 2005
Last Verified: December 2005
Keywords provided by University of Rochester:
Hearing Loss, Central
Presbycusis
Hearing Loss, Sensorineural
Hearing Loss, Cochlear
Hearing Loss, Bilateral
Sex Steroid Hormones
Estradiol
Additional relevant MeSH terms:
Layout table for MeSH terms
Hearing Loss
Auditory Perceptual Disorders
Perceptual Disorders
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Neurobehavioral Manifestations
Auditory Diseases, Central
Retrocochlear Diseases
Brain Diseases
Central Nervous System Diseases
Cognition Disorders
Neurocognitive Disorders
Mental Disorders
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs