Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection
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ClinicalTrials.gov Identifier: NCT00259350 |
Recruitment Status
:
Completed
First Posted
: November 29, 2005
Last Update Posted
: January 27, 2009
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The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions. No study has compare alcoholic formulations of low concentration of chlorhexidine and povidone iodine for skin disinfection prior to insertion of central venous catheters.
To compare the incidence of central venous catheter colonization after skin disinfection with either an alcoholic solution of povidone iodine or a combination of 0.5% chlorhexidine, 0.025% Benzalkonium and 4% benzylic alcohol.
To compare the incidence of catheter related bacteremia in the to study groups. To compare the local and general tolerance of the two antiseptic formulations
Condition or disease | Intervention/treatment | Phase |
---|---|---|
ICU Patients Requiring a Central Venous Access | Drug: Skin disinfection | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 520 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Prevention of Central Venous Catheter Infections : Comparison of the Efficacy of Skin Disinfection With 5% Povidone Iodine in Alcoholic Solution Versus 0.25% Chlorhexidine, 0.025 Benzalkonium and 4% Benzylic Alcohol |
Study Start Date : | May 2004 |
Study Completion Date : | April 2006 |

- Prevention of catheter colonization
- Prevention of catheter related bacteremia
- Prevention of a positive culture of the catheter whaterver the threshold
- Local and general tolerance

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients over 18 yeras of age
- Requiring an internal jugular or sub-clavian central venous catheter for their care during at least 72 h
- Informed consent signed up
Exclusion Criteria:
- Bacteriemic infection not under control
- extensive cutaneous infection
- Women with childbearing potential

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00259350
France | |
University hospital | |
Poitiers, Vienne, France, 86021 |
Study Chair: | Olivier MIMOZ, MD, PhD | University Hospital of Poitiers, france |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: | NCT00259350 History of Changes |
Other Study ID Numbers: |
Anticath |
First Posted: | November 29, 2005 Key Record Dates |
Last Update Posted: | January 27, 2009 |
Last Verified: | January 2009 |
Keywords provided by Poitiers University Hospital:
Central venous catheter Skin disinfection Antisepsis Nosocomial infection Catheter infection |
Additional relevant MeSH terms:
Infection Chlorhexidine Chlorhexidine gluconate Povidone-Iodine Povidone Anti-Infective Agents, Local |
Anti-Infective Agents Disinfectants Dermatologic Agents Plasma Substitutes Blood Substitutes |