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Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection

This study has been completed.
Information provided by:
Poitiers University Hospital Identifier:
First received: November 27, 2005
Last updated: January 26, 2009
Last verified: January 2009

The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions. No study has compare alcoholic formulations of low concentration of chlorhexidine and povidone iodine for skin disinfection prior to insertion of central venous catheters.

To compare the incidence of central venous catheter colonization after skin disinfection with either an alcoholic solution of povidone iodine or a combination of 0.5% chlorhexidine, 0.025% Benzalkonium and 4% benzylic alcohol.

To compare the incidence of catheter related bacteremia in the to study groups. To compare the local and general tolerance of the two antiseptic formulations

Condition Intervention Phase
ICU Patients Requiring a Central Venous Access Drug: Skin disinfection Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Prevention of Central Venous Catheter Infections : Comparison of the Efficacy of Skin Disinfection With 5% Povidone Iodine in Alcoholic Solution Versus 0.25% Chlorhexidine, 0.025 Benzalkonium and 4% Benzylic Alcohol

Resource links provided by NLM:

Further study details as provided by Poitiers University Hospital:

Primary Outcome Measures:
  • Prevention of catheter colonization

Secondary Outcome Measures:
  • Prevention of catheter related bacteremia
  • Prevention of a positive culture of the catheter whaterver the threshold
  • Local and general tolerance

Estimated Enrollment: 520
Study Start Date: May 2004
Estimated Study Completion Date: April 2006

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients over 18 yeras of age
  • Requiring an internal jugular or sub-clavian central venous catheter for their care during at least 72 h
  • Informed consent signed up

Exclusion Criteria:

  • Bacteriemic infection not under control
  • extensive cutaneous infection
  • Women with childbearing potential
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Please refer to this study by its identifier: NCT00259350

University hospital
Poitiers, Vienne, France, 86021
Sponsors and Collaborators
Poitiers University Hospital
Study Chair: Olivier MIMOZ, MD, PhD University Hospital of Poitiers, france
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00259350     History of Changes
Other Study ID Numbers: Anticath
Study First Received: November 27, 2005
Last Updated: January 26, 2009

Keywords provided by Poitiers University Hospital:
Central venous catheter
Skin disinfection
Nosocomial infection
Catheter infection

Additional relevant MeSH terms:
Chlorhexidine gluconate
Anti-Infective Agents, Local
Anti-Infective Agents
Dermatologic Agents
Plasma Substitutes
Blood Substitutes processed this record on August 18, 2017