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Long-term Observation of Patients With Early Rheumatoid Arthritis

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ClinicalTrials.gov Identifier: NCT00240136
Recruitment Status : Active, not recruiting
First Posted : October 17, 2005
Last Update Posted : February 19, 2016
Sponsor:
Information provided by (Responsible Party):
Harold E. Paulus, University of California, Los Angeles

Brief Summary:
The purpose of this research is to observe the effects of RA over a long period in order to learn which of the early characteristics of patients' early RA predict future joint damage and disability. We also investigate whether certain treatments can prevent or slow the development of joint damage and disability. Additionally, the costs and effects of RA on the patient are studied in order to improve the methods used to measure these effects. Clinical, demographic, radiographic, and laboratory measures are taken by the rheumatologist in the office. In addition, patient questionnaires are mailed & completed by the patient and returned to the coordinating center at UCLA. All information obtained by these means will be studied in their effects on early, severe RA.

Condition or disease
Rheumatoid Arthritis

Detailed Description:
See Publications

Study Type : Observational
Actual Enrollment : 372 participants
Observational Model: Cohort
Official Title: Long-term Observation of Patients With Early Rheumatoid Arthritis
Study Start Date : January 1993
Estimated Primary Completion Date : December 2022
Estimated Study Completion Date : July 2023

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Development of joint erosions in the early stages of RA [ Time Frame: Baseline, Annual Follow-up ]
    Measure joint erosions over time



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with rheumatoid arthritis
Criteria

Inclusion Criteria:

  • >=6 swollen joints & >=9 tender joints
  • symmetrical rheumatoid arthritis (RA)
  • <= 2 years worth of symptoms
  • rheumatoid factor seropositivity

Exclusion Criteria:

  • <18 years old
  • Inability to see rheumatologist, complete questionnaires (lack of compliance)
  • >2 years worth of symptoms

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00240136


Locations
United States, California
UCLA
Los Angeles, California, United States, 90095
Sponsors and Collaborators
University of California, Los Angeles
Investigators
Principal Investigator: Harold E Paulus, MD University of California, Los Angeles

Publications of Results:

Responsible Party: Harold E. Paulus, Professor, University of California, Los Angeles
ClinicalTrials.gov Identifier: NCT00240136     History of Changes
Other Study ID Numbers: 91-10-435-32
First Posted: October 17, 2005    Key Record Dates
Last Update Posted: February 19, 2016
Last Verified: February 2016

Keywords provided by Harold E. Paulus, University of California, Los Angeles:
Early, severe

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases