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Prospective Study of Patients With Hirsutism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00145288
Recruitment Status : Unknown
Verified March 2007 by Odense University Hospital.
Recruitment status was:  Active, not recruiting
First Posted : September 5, 2005
Last Update Posted : March 26, 2007
Information provided by:
Odense University Hospital

Brief Summary:

Hirsutism is the presence of terminal hairs in a male-like pattern in females, due to elevated male hormone levels. Females with hirsutism are often overweight and have metabolism disturbances as insulin resistance and impaired glucose tolerance.

The previous studies showed that patients with hirsutism (especially them with polycystic ovarian syndrome (PCOS)) have an increased risk to develop type 2 diabetes mellitus on the background of insulin resistance / hyperinsulinemia: 30-35 % of females with PCOS had impaired glucose tolerance and 5-10 % of them diabetes. Hyperinsulinemia increases the risk to develop dyslipidemia and cardiovascular diseases.

A previous study in our department who included 340 females with hirsutism (210 with idiopathic hirsutism and 134 with PCOS) showed that 6.6% of them had diabetes and 55% insulin resistance.

There were only few long-term follow up studies of patients with hirsutism concerning their risk to develop diabetes. As far as we now, such studies on patients with idiopathic hirsutism are not available until now.

Hirsutism is been treated with low dose oral contraceptives, which are suppressing androgen production. This treatment can also influence the risk to develop diabetes and atheromatosis. The previous studies showed that the low dose oral contraceptives had modest influence on the lipid profiles and carbohydrate metabolism in patients with hirsutism, but increased the risk to develop coronary disease.


  • To study and quantify, in patients with hirsutime, the risk to develop type 2 diabetes on the background of insulin resistance / decreased glucose tolerance and atheromatosis on the background of insulin resistance / hypercholesterolemia.
  • To clarify the effect of P-pills on patients hair growth and metabolism.

Condition or disease
Hirsutism Type 2 Diabetes Polycystic Ovary Syndrome

  Show Detailed Description

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Study Type : Observational
Enrollment : 340 participants
Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Prospective Study of Patients Med Hirsutism as Primary Work Diagnose
Study Start Date : October 2003
Study Completion Date : March 2005

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • The patients which had been included in the previous study between 1997 – 2000, oral glucose tolerance test included.

Exclusion Criteria:

  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00145288

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Department of Endocrinology, Odense University Hospital
Odense, Funen, Denmark, 5000
Sponsors and Collaborators
Odense University Hospital
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Principal Investigator: Magdalena Andries, MD Odense University Hospital

Layout table for additonal information Identifier: NCT00145288     History of Changes
Other Study ID Numbers: 010
First Posted: September 5, 2005    Key Record Dates
Last Update Posted: March 26, 2007
Last Verified: March 2007

Keywords provided by Odense University Hospital:
type 2 diabetes
polycystic ovary syndrome

Additional relevant MeSH terms:
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Diabetes Mellitus, Type 2
Polycystic Ovary Syndrome
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Ovarian Cysts
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Gonadal Disorders
Hair Diseases
Skin Diseases
Signs and Symptoms