Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts
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ClinicalTrials.gov Identifier: NCT00023036 |
Recruitment Status
:
Recruiting
First Posted
: August 22, 2001
Last Update Posted
: March 29, 2018
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This study will try to identify and understand the genetic factors that lead to an inner ear malformation called "enlarged vestibular aqueducts", that can be associated with hearing loss.
Patients with sensorineural hearing loss with or without inner ear malformations and their parents and siblings may be eligible for this study. Participants and their immediate family members, may undergo some or all of the following tests and procedures:
- Medical and family history, including questions about hearing, balance and other ear-related issues, and review of medical records.
- Routine physical examination.
- Blood draw or buccal swab (brushing inside the cheek to collect cells) - Tissue is collected for DNA analysis to look for changes in genes that may be related to hearing loss.
- Hearing tests - The subject listens for tones emitted through a small earphone.
- Balance test (VEMP) to see if balance functions of the inner ear are associated with the hearing loss Electrodes will be placed behind your ear and at the base of your neck. From a reclining position, you will be asked to raise your head while clicking sounds are played into your ears. - Ultrasound tests - An inner ear malformation called EVA (enlargement of the vestibular aqueduct) indicates that a genetic disorder called Pendred syndrome may be the cause. Because thyroid abnormalities are also associated with Pendred syndrome, an ultrasound examination of the thyroid gland may be done.
- Computed tomography (CT) and magnetic resonance imaging (MRI) scans - These tests show the structure of the inner ear. For CT, the subject lies still for a short time while X-ray images are obtained. For MRI, the patient lies on a stretcher that is moved into a cylindrical machine with a strong magnetic field. The magnetic field and radio waves produce images of the inner ear. The radio waves cause loud thumping noises that can be muffled by the use of earplugs.
Condition or disease |
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Sensorineural Hearing Loss Cytomegalovirus Infection |
Study Type : | Observational |
Estimated Enrollment : | 500 participants |
Time Perspective: | Other |
Official Title: | Clinical and Molecular Analysis of Enlarged Vestibular Aqueducts |
Study Start Date : | August 17, 2001 |


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Ages Eligible for Study: | up to 99 Years (Child, Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
- INCLUSION CRITERIA:
Subjects must have or be a family member of a participant with known or non-syndromic SNHL associated with inner ear malformations
There must be at least two participating affected family members.
Adults must be able to provide informed consent
Minors must have a parent or guardian able to provide consent
Age between 0-99.
EXCLUSION CRITERIA:
Subjects with known exposure to physical or chemical teratogens in utero that could account for their inner ear malformations such as thalidomide or radiation
Any hearing loss that is associated with syndromes, such as, branchio-oto-renal (BOR) syndrome, which comprises system malformations and branchial cleft abnormalities and is caused by heterozygous mutations in the EYA1 gene.
Previous genetic testing identifying two pathogenic mutant alleles of SLC26A4.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00023036
Contact: Jessica S Ratay | (301) 435-1574 | jessica.ratay@nih.gov | |
Contact: Andrew J Griffith, M.D. | (301) 402-2829 | griffita@mail.nih.gov |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 | |
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov |
Principal Investigator: | Andrew J Griffith, M.D. | National Institute on Deafness and Other Communication Disorders (NIDCD) |
Additional Information:
Publications:
Responsible Party: | National Institute on Deafness and Other Communication Disorders (NIDCD) |
ClinicalTrials.gov Identifier: | NCT00023036 History of Changes |
Other Study ID Numbers: |
010228 01-DC-0228 |
First Posted: | August 22, 2001 Key Record Dates |
Last Update Posted: | March 29, 2018 |
Last Verified: | March 13, 2018 |
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute on Deafness and Other Communication Disorders (NIDCD) ):
Genetics Deafness EVA Pendred Hearing |
Hearing Impairment Nonsyndromic Hereditary Hearing Impairment SNHL Inner Ear Enlarged Vestibular Aqueducts |
Additional relevant MeSH terms:
Hearing Loss Cytomegalovirus Infections Hearing Loss, Sensorineural Hearing Disorders Ear Diseases Otorhinolaryngologic Diseases Sensation Disorders |
Neurologic Manifestations Nervous System Diseases Signs and Symptoms Herpesviridae Infections DNA Virus Infections Virus Diseases |