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Dichloroacetate Kinetics, Metabolism and Toxicology

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00015015
First Posted: April 19, 2001
Last Update Posted: September 4, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Condition Intervention
Lactic Acidosis Drug: Dichloroacetate

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 100
Study Start Date: December 1994
Estimated Study Completion Date: October 2002
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Months to 65 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
Children with congenital lactic acidosis Healthy adult volunteers
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00015015


Locations
United States, Florida
Univ. of Florida
Gainesville, Florida, United States, 32610
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information

ClinicalTrials.gov Identifier: NCT00015015     History of Changes
Other Study ID Numbers: 7355-CP-001
First Submitted: April 17, 2001
First Posted: April 19, 2001
Last Update Posted: September 4, 2006
Last Verified: September 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Dichloroacetate
Chlorinated hydrocarbons
Genetic disease
Toxicology
Biotransformation

Additional relevant MeSH terms:
Acidosis
Acidosis, Lactic
Acid-Base Imbalance
Metabolic Diseases