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Non-Invasive Electrical Stimulation of the Human Brain

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00001216
First Posted: December 10, 2002
Last Update Posted: March 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institutes of Health Clinical Center (CC)
  Purpose

This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders.

Transcranial electrical stimulation is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function. Electrical stimulation involves placing electrodes on the scalp or skin and passing an electrical current between them. When this is done, an electrical field is created that activates areas of the brain that control muscles. Muscle activity as a result of the stimulation can be recorded and analyzed.


Condition
Cerebrovascular Disorders Healthy Nervous System Diseases Spinal Cord Injuries

Study Type: Observational
Official Title: Non-Invasive Stimulation of the Human Central Nervous System (Digitimer)

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 175
Study Start Date: February 1986
Estimated Study Completion Date: February 2001
Detailed Description:
This protocol application is written to permit us to use transcranial electrical stimulation, a safe and noninvasive method for activating the brain, spinal cord, or proximal nerves through the skin, in appropriate subjects. We will use this technique to explore the function of the human central and peripheral nervous system and to aid in the diagnosis of neurological disorders.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Males and females, ages 18 and over.

Diverse racial groups.

Amputees and others with whom we will have no patient-care relationship may also be considered to be volunteers.

Patients will be recruited from those referred to the Human Motor Control Section, NINDS who have neurological syndromes that are of interest.

On rare occasions we may attempt to study children as young as 10 years with TES.

Individuals without indwelling cardiac lines and pacemakers.

Patients recruited for study would come from those referred to the EMG laboratory and to the Human Motor Control Clinic who would have distinct neurologic syndromes from well defined peripheral and central nervous system lesions including hemiplegia from stroke, trauma, tumor or focal demyelination (most commonly patients would have hemiplegia from stroke), peripheral nerve lesions, amputations, spinal cord injury.

Normal volunteers, including NIH employees, would be healthy adults without history of physical examination evidence of neurologic disease and individuals with different types of amputations involving upper and lower extremities.

Volunteers may also be participants in the electrophysiological protocol (84-N-0196).

No history of epilepsy.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001216


Locations
United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00001216     History of Changes
Other Study ID Numbers: 860020
86-N-0020
First Submitted: November 3, 1999
First Posted: December 10, 2002
Last Update Posted: March 4, 2008
Last Verified: December 1999

Keywords provided by National Institutes of Health Clinical Center (CC):
Amputations
Brainstem Stimulation
Cerebellar Stimulation
Cortical Motor Physiology
Electrical Stimulation
Motor Cortex
Plasticity
Spinal Cord Injury
Stroke

Additional relevant MeSH terms:
Spinal Cord Injuries
Nervous System Diseases
Cerebrovascular Disorders
Spinal Cord Diseases
Central Nervous System Diseases
Trauma, Nervous System
Wounds and Injuries
Brain Diseases
Vascular Diseases
Cardiovascular Diseases