ClinicalTrials.gov
ClinicalTrials.gov Menu

Dutch Prediction of Psychosis Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00188981
Recruitment Status : Unknown
Verified April 2007 by UMC Utrecht.
Recruitment status was:  Active, not recruiting
First Posted : September 16, 2005
Last Update Posted : April 20, 2007
Sponsor:
Collaborators:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ZonMw: The Netherlands Organisation for Health Research and Development
Information provided by:
UMC Utrecht

Brief Summary:

The Dutch Prediction of Psychosis Study (DUPS) is a prospective study of predictors of the transition to psychosis in help-seeking adolescents at high risk for developing a first psychotic episode. The aim of the project is supplemented by a systematic account of the pathways to care, the disabilities and needs and the therapeutic interventions that are currently used in this population.

Multi-level assessment includes behavioral and cognitive variables as well as structural brain imaging and neurophysiological data. Subjects will be followed up at regular intervals during (at least) two years to monitor the development of their (psychotic) symptoms. This will allow us to analyze the predictive validity of the variables.


Condition or disease
Psychotic Disorders

  Show Detailed Description

Study Type : Observational
Enrollment : 120 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective
Official Title: Dutch Prediction of Psychosis Study
Study Start Date : June 2003
Estimated Study Completion Date : June 2008

Resource links provided by the National Library of Medicine






Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   12 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion criteria:

Help-seeking adolescents who belong to one or more of the following groups:

  • Basic symptoms: presence of self-perceived cognitive thought disturbances
  • Familial risk plus reduced functioning: having a first- or second degree relative with a history of any psychotic disorder in combination with a deterioration of mental state and/or social functioning in the last year
  • Attenuated psychotic symptoms: presence of psychotic symptoms at sub-clinical level
  • Brief, limited or intermittent psychotic symptoms: having a history of psychotic symptoms with a duration of less than one week and spontaneous remission
  • Multiple Complex Developmental disorder

Exclusion criteria:

  • A previous psychotic episode for more than one week
  • Verbal IQ < 75
  • Symptoms are due to an organic mental disorder or substance abuse

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00188981


Locations
Netherlands
University Medical Center Utrecht, department of Child and Adolescent Psychiatry
Utrecht, Netherlands
Sponsors and Collaborators
UMC Utrecht
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ZonMw: The Netherlands Organisation for Health Research and Development
Investigators
Principal Investigator: Patricia Schothorst, PhD University Medical Center Utrecht, department of Child and Adolescent Psychiatry
Principal Investigator: Herman van Engeland, Professor University Medical Center Utrecht, department of Child and Adolescent Psychiatry

ClinicalTrials.gov Identifier: NCT00188981     History of Changes
Other Study ID Numbers: CCMOP02.0441C
METC02/178
First Posted: September 16, 2005    Key Record Dates
Last Update Posted: April 20, 2007
Last Verified: April 2007

Keywords provided by UMC Utrecht:
psychosis
high risk
prodrome
Multiple Complex Developmental Disorder

Additional relevant MeSH terms:
Psychotic Disorders
Mental Disorders
Schizophrenia Spectrum and Other Psychotic Disorders