1.01.05 2022:06:23 23:12:38.411 moyamoya 419313 38 1 1 1 NCT05160454 16NC24 Great Ormond Street Hospital for Children NHS Foundation Trust OTHER NIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya NIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya NIRS moyamoya November 2021 Suspended COVID19 No February 14, 2018 Actual June 30, 2022 Anticipated June 30, 2022 Anticipated November 8, 2019 December 2, 2021 December 16, 2021 Actual December 2, 2021 December 16, 2021 Actual Sponsor Great Ormond Street Hospital for Children NHS Foundation Trust OTHER No No No Near infrared spectroscpy is a validated method of evaluating cerebral blood flow. The aim in this pilot study to explore its use in children with moyamoya disease. Moyamoya disease is a cerebrovascular condition in which there is chronic brain hypoperfusion. As surgery can possibly augment brain blood flow, a method for evalutaing cerebrovascualr reserve would be helpful in selecting patients for intervention. Near infrared spectroscopy (NIRS) is a validated non-invasive method of evaluating cerebral blood flow. We aim to investigate the feasibility and tolerability of using NIRS haemodynamic reserve in children with moyamoya and controls by evaluating cerebral blood flow in the baseline state and after breath-holding. Feasibility will be assessed by how many successful studies are carried out. Tolerability will be assessed by asking children some simple questions about their experience. Moyamoya Interventional Not Applicable Non-Randomized Single Group Assignment patients and controls Other None (Open Label) 20 Anticipated patient Active Comparator child with moyamoya Device: near infrared spectroscopy control Active Comparator unaffected control Device: near infrared spectroscopy Device near infrared spectroscopy evaluate cerebral blood flow with and without breatholding control patient Number of NIRS studies that can be completed in moyamoya patients how many studies can be completed 2years Patient questionnaire to evaluate children's experience of NIRS in moyamoya ask children re their experience 2years Inclusion Criteria: Patients with moyamoya and unaffected healthy controls - Exclusion Criteria: age <6 - Accepts Healthy Volunteers All 6 Years 18 Years Child Adult Great Ormond Street Hospital for Children NHS Foundation Trust London WC1N 3JH United Kingdom No June 24, 2022 D000009072 Moyamoya Disease D000002340 Carotid Artery Diseases D000002561 Cerebrovascular Disorders D000001927 Brain Diseases D000002493 Central Nervous System Diseases D000009422 Nervous System Diseases D000002539 Cerebral Arterial Diseases D000020765 Intracranial Arterial Diseases D000001157 Arterial Occlusive Diseases D000014652 Vascular Diseases D000002318 Cardiovascular Diseases M11184 Moyamoya Disease Moyamoya high M4746 Carotid Artery Diseases low M4962 Cerebrovascular Disorders low M4356 Brain Diseases low M4894 Central Nervous System Diseases low M4940 Cerebral Arterial Diseases low M21674 Intracranial Arterial Diseases low M3617 Arterial Occlusive Diseases low M16552 Vascular Diseases low T3892 Moyamoya Disease Moyamoya high BC10 Nervous System Diseases BC14 Heart and Blood Diseases All All Conditions Rare Rare Diseases