1.01.02
2021:03:02 22:19:02.771
moyamoya
369328
31
1
1
1
NCT03613701
8157113
Affiliated Hospital to Academy of Military Medical Sciences
OTHER
Relationship Between Endothelial Progenitor Cells and Revascularization Effect of Moyamoya Disease
Relationship Between Endothelial Progenitor Cells and Revascularization Effect of Moyamoya Disease
REPCREMMD
January 2019
Unknown status
Recruiting
No
September 1, 2017
Actual
September 1, 2019
Anticipated
December 1, 2020
Anticipated
July 29, 2018
August 2, 2018
August 3, 2018
Actual
January 29, 2019
January 31, 2019
Actual
Sponsor
Affiliated Hospital to Academy of Military Medical Sciences
OTHER
No
No
Moyamoya disease is a chronic cerebrovascular diseaseļ¼The typical pathological manifestations are the stenosis or occlusion of the distal internal carotid artery and/or middle cerebral artery, and the proximal anterior cerebral artery. Meanwhile, the abnormal vascular net, which is the smokey vessel, occurs at the bottom of the brain. Currently the pathogenesis of this disease is unknown. Limited studies have reported the expression of endothelial progenitor cells (EPCs) in moyamoya disease, but the results were inconsistent. Some investigators believe that the number of EPCs in peripheral blood of patients with moyamoya disease is increased, while others believe that the number of EPCs in peripheral blood of moyamoya patients is reduced. Therefore, the investigators need to find a more accurate detection method to confirm the growth of EPC in patients with moyamoya disease. At the same time, whether there is endothelial injury in patients with smoke disease, and the expression of endothelial cells (CEC) in patients with smoke disease, there is no research on this aspect at home and abroad.
Objective: Detect the expression of endothelial progenitor cells and endothelial cells from peripheral blood of patients with moyamoya disease, and to assess the relationship between clinical characteristics.
Design: A single center study, and planned to enroll 120 patients. The present study was to detect the quantities of EPC from peripheral blood in Moyamoya disease by flow cytometry, and to identify the relationship of endothelial progeIlitor cells and effect of the revascularization on Moyamoya disease. The present study also use cerebral ischemia animal model foe intervention experiment, to explore whether EPC can promote vascular remodeling effect of ischemic cerebrovascular disease, and to provide new thought for the treatment of chronic cerebrovascular disorder.
Moyamoya Disease
Moyamoya disease
Endothelial progenitor cells
revascularization
Observational
Yes
6 Months
Case-Control
Prospective
120
Anticipated
Moyamoya disease patients
Moyamoya disease patients/Healthy volunteers
Expression of endothelial progenitor cells and endothelial cells in peripheral blood
Expression of endothelial progenitor cells and endothelial cells in peripheral
2017.9-2018.8
Inclusion Criteria:
Whole-brain vessels angiography or magnetic resonance arteriography (MRA) has the following manifestations: stenosis or occlusion of terminal internal carotid artery or the anterior cerebral artery and/or initiating middle cerebral artery; In the arterial phase, the abnormal smokey vascular net near the occlusive or stenosis lesion can be seen.
For patients with stable stroke, there was no acute or subacute cerebral infarction or cerebral hemorrhage, and at least 3 months before the last cerebral infarction or cerebral hemorrhage events.
Exclusion Criteria:
Exclude atherosclerosis, autoimmune diseases, meningitis, intracranial tumors, multiple neurofibromatosis, Down syndrome, craniocerebral trauma, radiation injury, and other underlying diseases that may cause smoke.
Acute or subacute cerebral infarction or cerebral hemorrhage were excluded.
Accepts Healthy Volunteers
All
18 Years
60 Years
Adult
Health volunteers' inclusion criteria:
Age between 18-60;
Male or female;
Exclusion criteria:
Exclude the volunteers with history of cerebrovascular disease and heart disease.
Probability Sample
Lian Duan, Chief
Contact
0086-10-66947156
keyan307@163.com
Lian Duan, Chief
The 307th Hospital of Military Chinese People's Liberation Army
Study Chair
The 307th Hospital of Military Chinese People's Liberation Army
Recruiting
Beijing
Beijing
100071
China
Lian Duan, Chief
Contact
0086-10-66947156
keyan307@163.com
No
March 03, 2021
D000009072
Moyamoya Disease
D000002340
Carotid Artery Diseases
D000002561
Cerebrovascular Disorders
D000001927
Brain Diseases
D000002493
Central Nervous System Diseases
D000009422
Nervous System Diseases
D000002539
Cerebral Arterial Diseases
D000020765
Intracranial Arterial Diseases
D000001157
Arterial Occlusive Diseases
D000014652
Vascular Diseases
D000002318
Cardiovascular Diseases
M10615
Moyamoya Disease
Moyamoya Disease
high
M4176
Carotid Artery Diseases
low
M4393
Cerebrovascular Disorders
low
M3786
Brain Diseases
low
M4325
Central Nervous System Diseases
low
M4371
Cerebral Arterial Diseases
low
M21105
Intracranial Arterial Diseases
low
M3046
Arterial Occlusive Diseases
low
M15983
Vascular Diseases
low
T3892
Moyamoya Disease
Moyamoya Disease
high
BC10
Nervous System Diseases
BC14
Heart and Blood Diseases
All
All Conditions
Rare
Rare Diseases