Eye Pressure Lowering Surgery (IOP)
The purpose of this study is to determine if lowering the pressure inside the eye improves blood flow to the eye.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||OBSERVATIONAL STUDY OF OCULAR BLOOD FLOW PRE- AND POST- TRABECULECTOMY SURGERY USING FUNCTIONAL AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY|
- Effects of Intraocular Pressure (IOP) Reduction on Ocular Perfusion [ Time Frame: 6 months ] [ Designated as safety issue: No ]To determine if IOP reduction improves ocular perfusion.
|Study Start Date:||February 2014|
|Estimated Study Completion Date:||June 2015|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
20 glaucoma patients undergoing trabeculectomy surgery to lower IOP
20 patients undergoing cataract surgery will be selected as a control group
Using high-speed ocular coherence tomography (OCT) systems, we have developed new methods to image and measure optic nerve head (ONH) and retinal blood flow. Preliminary results have shown that visual field (VF) loss is more highly correlated with retinal blood flow as measured by OCT than any neural structure measured by OCT or other imaging modality. Accordingly, the goal of the proposed project is to improve the diagnostic and prognostic evaluation of glaucoma by further developing novel functional OCT measurements using ultrahigh-speed (70-100 kHz) OCT technology.
Retinal blood flow, ONH circulation, optic disc rim volume, peripapillary nerve fiber layer volume, and macular ganglion cell complex volume are all pieces of the same glaucoma puzzle. This project will develop novel imaging methods that allow us to look at the whole picture using one tool - ultrahigh-speed OCT.
|Contact: Janice Ladwigfirstname.lastname@example.org|
|Contact: Denny Romfhemail@example.com|
|United States, Oregon|
|Portland, Oregon, United States, 97239|
|Contact: Janice Ladwig 503-494-8024 firstname.lastname@example.org|
|Contact: Denny Romfh 503-494-4351 email@example.com|
|Sub-Investigator: Beth Edmunds, MD, Ph. D.|
|Sub-Investigator: Mansi Parikh, MD|
|Sub-Investigator: Hana Takusagawa, MD|
|Sub-Investigator: Rebecca Armour, MD|
|Sub-Investigator: Lorinna Lombardi, MD|
|Sub-Investigator: David Huang, MD, Ph. D.|
|Sub-Investigator: Shandiz Tehrani, MD|
|Principal Investigator:||John Morrison, MD||Oregon Health and Science University|