Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Nam-Jong Paik, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier:
NCT01877161
First received: March 11, 2013
Last updated: May 20, 2014
Last verified: May 2014
  Purpose

Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.


Condition Intervention
To Healthy Volunteer
Virtual Lesions for Aphasia
Device: Repetitive magnetic stimulation to superior temporal gyrus
Device: Repetitive magnetic stimulation to middle temporal gyrus
Device: Repetitive magnetic stimulation (Sham)

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

Resource links provided by NLM:


Further study details as provided by Seoul National University Bundang Hospital:

Primary Outcome Measures:
  • The Change of Reaction Time Between Before and After Stimulation in Each Session (MTG, STG, Sham) [ Time Frame: change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3) ] [ Designated as safety issue: No ]

    Reaction time for lexical and repetition test were measured before and after the TMS stimulation at each sessions (at session 1, session 2, session 3 over MTG/STG/Sham).

    Response times were measured via the response pad, and spoken responses were recorded via a SV-1 Voice Key apparatus.

    The "reaction time post TMS - reaction time pre TMS" were used for analysis.* Arm/Group Title Arm/Group Description Maximum length (999) Repetitive magnetic stimulation (rTMS) were applied over STG



Enrollment: 12
Study Start Date: December 2012
Study Completion Date: May 2013
Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Middle temporal gyrus
Repetitive magnetic stimulation to middle temporal gyrus
Device: Repetitive magnetic stimulation to middle temporal gyrus
Repetitive magnetic stimulation to middle temporal gyrus
Other Name: MagPro X100 magnetic stimulator
Sham Comparator: Control group
Repetitive magnetic stimulation (Sham)
Device: Repetitive magnetic stimulation (Sham)
Repetitive magnetic stimulation (Sham)
Other Name: MagPro X100 magnetic stimulator
Experimental: Superior temporal gyrus
Repetitive magnetic stimulation to superior temporal gyrus
Device: Repetitive magnetic stimulation to superior temporal gyrus
Repetitive magnetic stimulation to superior temporal gyrus
Other Name: MagPro X100 magnetic stimulator

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • fluent in Korean
  • older than 18 years old

Exclusion Criteria:

  • younger than 18 years old
  • psychotic or psychiatric problems
  • pregnant
  • contraindications to MRI/fMRI
  • uncooperative
  • metalic implants, pacemaker or cochlear implants
  • cannot perform outcome measure-related task
  • known seizure history
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01877161

Locations
Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Bundang-gu, Korea, Republic of, 463-707
Sponsors and Collaborators
Seoul National University Bundang Hospital
  More Information

No publications provided

Responsible Party: Nam-Jong Paik, Professor, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier: NCT01877161     History of Changes
Other Study ID Numbers: E-1206-158-003
Study First Received: March 11, 2013
Results First Received: January 23, 2014
Last Updated: May 20, 2014
Health Authority: Korea: Institutional Review Board

Additional relevant MeSH terms:
Aphasia
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on September 18, 2014