The Effect of Weight Loss on Ovarian Reserve
Obesity affects on fertility. Obese women have lower pregnancy rate after infertility treatments.They need more doses of hormone during ovarian stimulation, more days for stimulation. During IVF treatment less oocytes are collected and the quality of embryo also harmed.
The first line treatment for those women with obesity and infertility is weight loss.
The investigators' hypothesis is that weight reduction improves ovarian reserve and fertility treatment outcome.
|Study Type:||Observational [Patient Registry]|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Target Follow-Up Duration:||1 Year|
- Anti Mullerain Hormone (AMH)and AFC before and after weight loss [ Time Frame: 3 months ] [ Designated as safety issue: No ]AMH and AFC will measure at the first visit and after 3 months of weight loss program
|Study Start Date:||May 2013|
|Estimated Primary Completion Date:||April 2014 (Final data collection date for primary outcome measure)|
|overweight women with infertility||Dietary Supplement: weight loss|
The investigators have outpatient clinic for obesity and infertility. the patients undergoing program of 3 months with diet and physical activity. Blood sample will take at the beginning of the program and at the end. The blood sample will evaluate for: AMH, Adiponectin, Leptin, CRP, Colesterol, CRP, Smac in addition TVUS will perform to evaluate AFC.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01844128
|Contact: Amir Wiswe, MD||+97297472227|
|Meir Medical Center||Recruiting|
|Kfar Sava, Israel|
|Contact: Overweight &Infertility clinic 097471555|
|Principal Investigator: Amir Wiser, MD|