Adiponectin and Ethnic Differences in Insulin Resistance

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Colorado, Denver
ClinicalTrials.gov Identifier:
NCT01831102
First received: April 5, 2013
Last updated: April 9, 2013
Last verified: April 2013
  Purpose

The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.


Condition Intervention
Insulin Resistance
Type 2 Diabetes
Other: none- observational study

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance

Resource links provided by NLM:


Further study details as provided by University of Colorado, Denver:

Primary Outcome Measures:
  • total adiponectin concentration [ Time Frame: measured once during second study visit, in fasting condition ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Insulin sensitivity [ Time Frame: Measured once, during second study visit. ] [ Designated as safety issue: No ]
    Calculated from insulin and glucose values obtained during IV glucose tolerance test.


Enrollment: 43
Study Start Date: March 2011
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
non-Latino white
no Latino ancestry, Caucasian
Other: none- observational study
Mexican American
Mexican American ancestry
Other: none- observational study

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Community sample

Criteria

Inclusion Criteria:

  • 18-60 years of age
  • BMI 20.0-34.9 m/kg2
  • Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion Criteria:

  • pregnancy
  • breastfeeding
  • diabetes mellitus
  • blood pressure > 160/100 mmHg
  • creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
  • liver function tests > 3x upper limit of normal (ULN)
  • h/o heart failure
  • h/o eating disorder
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01831102

Locations
United States, Colorado
University of Colorado Anschutz Medical Center
Aurora, Colorado, United States, 80045
Sponsors and Collaborators
University of Colorado, Denver
Investigators
Principal Investigator: Rocio Pereira, MD University of Colorado, Denver
  More Information

No publications provided

Responsible Party: University of Colorado, Denver
ClinicalTrials.gov Identifier: NCT01831102     History of Changes
Other Study ID Numbers: 10-1260
Study First Received: April 5, 2013
Last Updated: April 9, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Colorado, Denver:
insulin resistance
ethnic disparities
adiponectin

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Insulin Resistance
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hyperinsulinism
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on April 22, 2014