Metabolomics Fingerprinting and Metabolic Dynamis After HIV Infection
The purpose of this plot study is to find out the relationship between metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions of HIV-infected patients using nuclear magnetic resonance (NMR) based systems biology approach and metabolomics methodology.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Metabolic Fingerprintings and Metabolic Dynamics After HIV Infection:Impact of Metabolic Changes and Anti-Retroviral Therapy, Life Style and Clinical Conditions|
- Dyslipidemia [ Time Frame: Dyslipidemia events from admission to discharge(Up to 6 months) ) ] [ Designated as safety issue: No ]
- Lipoatrophy [ Time Frame: Lipoarophy events from admission to discharge (up to 6 months) ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Plasma from peripheral blood
|Study Start Date:||March 2013|
|Estimated Study Completion Date:||March 2020|
|Estimated Primary Completion Date:||March 2019 (Final data collection date for primary outcome measure)|
100 confirmed HIV-1 infected patients who meet inclusion criteria.
Since the clinical application of anti-retroviral therapy (ART) in 1997, the life expectancy of HIV infected patients has been prolonged greatly. However,side effects of ART including metabolic abnormalities have become the main factors influencing patients' quality of life. Among which the abnormal lipid metabolism plays an important role. Meanwhile, metabolic conditions differ from patients applying to different combinations of ART drugs,life style and clinical conditions.
Metabolomics can measure the dynamic metabolic responses of the body to stimuli or modifications. Using nuclear magnetic resonance (NMR) as tools can systematically analyse the process of lipid metabolism. Metabolomics fingerprinting can be defined as the complete complement of small molecule (< 1500 Da) metabolites found in a specific cell, body fluid, organ or organism.
Therefore, the study of the impact of metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions is of importance in enhancing the adherence and improving the clinical outcomes of HIV infected patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01828268
|Contact: Hua JIANG, PhDfirstname.lastname@example.org|
|Contact: Bing CAI, Master||+86-28-88424391|
|Sichuan Academy of Medical Sciences,Sichuan Provincial Hospital, Metabolomics and Mutidisciplinary Laboratory||Recruiting|
|Chengdu, Sichuan, China, 610101|
|Contact: Hua JIANG, PhD +86-28-88424391 email@example.com|
|Principal Investigator: Jin PENG, Master|
|Study Chair:||Hua JIANG, PhD||3Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, East Branch, Metabonomics and Multidisciplinary Laboratory|
|Principal Investigator:||Jin PENG, Master||3Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, East Branch, Metabonomics and Multidisciplinary Laboratory|