Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Oras Alabas, University of Leeds
ClinicalTrials.gov Identifier:
NCT01808027
First received: March 7, 2013
Last updated: NA
Last verified: March 2013
History: No changes posted
  Purpose

To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.


Condition
Acute Myocardial Infarction

Study Type: Observational [Patient Registry]
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 12 Months
Official Title: Evaluation of the Methods and Management of Acute Coronary Events: 3. Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

Resource links provided by NLM:


Further study details as provided by University of Leeds:

Primary Outcome Measures:
  • delays to treatment [ Time Frame: 12 months ] [ Designated as safety issue: Yes ]
    Quantification of hospital attributable effects relating to early and late mortality


Secondary Outcome Measures:
  • Describing trajectories of quality of life recovery patterns [ Time Frame: 12 month ] [ Designated as safety issue: Yes ]
    Describing trajectories of quality of life recovery patterns


Other Outcome Measures:
  • Develop a risk score and a near-point risk Acute Coronary Syndrome model [ Time Frame: two years ] [ Designated as safety issue: Yes ]
    Develop a risk score and a near-point risk Acute Coronary Syndrome model


Biospecimen Retention:   Samples With DNA

Blood


Enrollment: 5555
Study Start Date: February 2011
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Acute myocardial infarction
patient with suspected acute coronary syndrome (ACS).

Detailed Description:

Over the last few years the chance of dying from a heart attack in England and Wales has reduced dramatically. Even so, there remain huge differences in mortality between hospitals. For example, up to a third of patients with a heart attack who attend hospitals in England are more likely to die than would be expected. That is, the type of treatment and the risk of death depends upon where a patient lives and which hospital they attend. In part, the variation in death may be due to the services available at the hospital or to factors such as socioeconomic deprivation. It may also relate to other factors such as depression, cardiac rehabilitation and whether patients take their medication after discharge from hospital. Using powerful statistical approaches that include measures of quality of life, we propose to examine data about heart attacks in England and investigate the 'postcode lottery of care'. Our aim, using regional data about heart attacks is to identify and measure the effects of hospital care. This research will identify hospital qualities that promote improved patient care. In doing so, best practice will be highlighted and healthcare policy changed so that all patients will have an equal chance of surviving a heart attack.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Consented patients with acute coronary syndrome were recruited from acute Trusts in England. These hospitals have been selected because of their diverse population demographics, different acute coronary syndrome care pathways and established track record for good data collection. Specifically these hospitals represent both teaching hospitals and community hospitals - but more importantly include a wide range of patient types. Mortality tracked through the UK statistics authority, and primary and secondary endpoints tracked locally and transferred through the secure NHS net to a central database.

Criteria

Inclusion Criteria:

  • Age > 18 years
  • Both sexes
  • Acute admission to the acute Trust with suspected acute coronary syndrome

Exclusion Criteria:

  • Patients at a terminal stage of any illness
  • Those in whom follow up would be inappropriate or impractical
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01808027

Locations
United Kingdom
University of Leeds
Leeds, West Yorkshire, United Kingdom, LS2 9JT
Sponsors and Collaborators
University of Leeds
Investigators
Principal Investigator: Chris P Gale, PhD University of Leeds
  More Information

No publications provided

Responsible Party: Oras Alabas, Dr, University of Leeds
ClinicalTrials.gov Identifier: NCT01808027     History of Changes
Other Study ID Numbers: 10/H1313/74
Study First Received: March 7, 2013
Last Updated: March 7, 2013
Health Authority: United Kingdom: National Institute for Health Research

Keywords provided by University of Leeds:
quality of life drug adherence drug compliance mortality

Additional relevant MeSH terms:
Acute Coronary Syndrome
Infarction
Myocardial Infarction
Angina Pectoris
Cardiovascular Diseases
Chest Pain
Heart Diseases
Ischemia
Myocardial Ischemia
Necrosis
Pain
Pathologic Processes
Signs and Symptoms
Vascular Diseases

ClinicalTrials.gov processed this record on October 23, 2014