Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation
The aim of this study is to compare the accuracy of PVI (pleth variability index)
|Study Design:||Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Diagnostic
|Official Title:||Accuracy and Utility of the Pleth Variability Index as a Predictor of Fluid Responsiveness During the Dissection and Anhepatic Phase of Liver Transplantation|
- To test the ability of PVI to detect changes in preload during orthotopic liver transplantation [ Time Frame: During dissection and anhepatic phase (3 months) ] [ Designated as safety issue: Yes ]PVI is a measure of the dynamic changes in perfusion index that occur during a complete respiratory cycle
|Study Start Date:||October 2012|
|Study Completion Date:||February 2013|
|Primary Completion Date:||February 2013 (Final data collection date for primary outcome measure)|
A new non-invasive device (Radical-7 pulse oximeter monitor, Masimo Corp.) has been introduced that continuously detects changes in the plethysmograph waveform and computes a Plethysmography Variability Index (PVI) reflecting alteration in preload and fluid management.
Device: PVI-guided fluid management
In this study of 25 adult patients undergoing OLT, we prospectively record PVIwithin 5 minutes during dissection and anhepatic phase of OLT by Masimo pulse oximeter.In this study of 25 adult patients undergoing OLT, we prospectively record study data within 5 minutes during dissection and anhepatic phase of OLT. Study data included measurements of PVI,thermodilution cardiac output, Stroke volume variation (SVV) and Pulse pressure variation (PPV).
The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01792011
|Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation|
|Malatya, Turkey, 44315|
|Study Chair:||Gulay Erdogan Kayhan, Dr||Inonu University Faculty of Medicine Anesthesiology and Reanimation Department|