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Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia

This study is currently recruiting participants.
Verified January 2013 by University of Konstanz
Sponsor:
Information provided by (Responsible Party):
Prof. Dr. Brigitte Rockstroh, University of Konstanz
ClinicalTrials.gov Identifier:
NCT01781364
First received: January 22, 2013
Last updated: January 30, 2013
Last verified: January 2013
History of Changes
  Purpose

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on course and rehabilitation in early onset schizophrenia


Condition Intervention
Psychosis
 Behavioral: Brain Fitness Training, Posit Science SF

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Konstanz:

Primary Outcome Measures:
  • change from baseline at post-training and at 3-months and at 7-months follow-up in each of the following outcome measures: neuropsychological test performance (MCCCB), GAF, PANSS, MEG event-related potentials (M50), alpha activity [ Time Frame: baseline, post-training (training duration 4 weeks), 3-month follow-up, 7-month follow-up ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • change from baseline in GAF score at 3-months and 7-moths follow-up [ Time Frame: baseline, 3-months follow-up, 7-months follow-up ] [ Designated as safety issue: No ]

Estimated Enrollment: 20
Study Start Date: January 2012
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive Training
Brain Fitness Training, Posit Science SF
 Behavioral: Brain Fitness Training, Posit Science SF
Computer aided cognitive training based on principles of neuroplasticity

Detailed Description:

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. We examine the beneficial effect of computer-aided training program on course and rehabilitation of young psychotic patients with early onset psychosis. In addition we develop predictors for the course of disorder from neuroimaging data.

  Eligibility

Ages Eligible for Study:   17 Years to 37 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Early Onset Psychosis

Exclusion Criteria:

  • Chronicity
  • Insufficient German skills
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01781364

Locations
Germany
University Konstanz Recruiting
Konstanz, Baden Wuerttemberg, Germany, 78464
Contact: Brigitte Rockstroh, Prof. Dr.     +497531884625     brigitte.rockstroh@uni-konstanz.de    
Principal Investigator: Brigitte Rockstroh, Prof. Dr.            
Sponsors and Collaborators
University of Konstanz
Investigators
Study Director: Brigitte S Rockstroh, Prof. Dr. University of Konstanz
  More Information

No publications provided

Responsible Party: Prof. Dr. Brigitte Rockstroh, Prof. Dr., University of Konstanz
ClinicalTrials.gov Identifier: NCT01781364     History of Changes
Other Study ID Numbers: FP16963311
Study First Received: January 22, 2013
Last Updated: January 30, 2013
Health Authority: Germany: University of Konstanz Ethics Committee

Keywords provided by University of Konstanz:
Brain Oscillations
Cognitive Performance

Additional relevant MeSH terms:
Mental Disorders
Psychotic Disorders
Schizophrenia
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on May 16, 2013