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Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified October 2012 by Hillel Yaffe Medical Center
Sponsor:
Information provided by (Responsible Party):
Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier:
NCT01718405
First received: October 10, 2012
Last updated: October 29, 2012
Last verified: October 2012
  Purpose

Studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise. The main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.


Condition Intervention
Executive Function
Other: Cognitive function after exercise test
Genetic: Blood sample analysis

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Primary Purpose: Basic Science

Resource links provided by NLM:


Further study details as provided by Hillel Yaffe Medical Center:

Primary Outcome Measures:
  • Cognitive Functioning After Exercise [ Time Frame: Five minutes ] [ Designated as safety issue: No ]
    Computerized battery of tests evaluating cognitive functioning


Other Outcome Measures:
  • Genetic Variation Associated with Different Cognitive Functioning [ Time Frame: Two years ] [ Designated as safety issue: No ]
    Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.


Estimated Enrollment: 150
Study Start Date: November 2012
Estimated Study Completion Date: November 2017
Estimated Primary Completion Date: November 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise Group
Each individual subject will give a blood sample for genetic analysis and undertake an exercise session and a rest session as a control. Cognitive function will be tested before and after each session.
Other: Cognitive function after exercise test
The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.
Genetic: Blood sample analysis
In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.

  Eligibility

Ages Eligible for Study:   20 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Physical Education Students
  • Able to sign consent form

Exclusion Criteria:

  • Competitive athletes
  • Smokers
  • Neurologic or psychologic orders
  • Chronic diseases
  • Head Injuries
  • Hospitalization in the previous 3 months
  • Pregnant
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01718405

Contacts
Contact: Sharon Tsuk, PhD 972-522-640642 sharontsuk1@gmail.com

Locations
Israel
Wingate Institute Not yet recruiting
Netanya, Israel
Principal Investigator: Raffael Carasso, MD         
Sub-Investigator: Sharon Tsuk, PhD         
Sponsors and Collaborators
Hillel Yaffe Medical Center
  More Information

No publications provided

Responsible Party: Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT01718405     History of Changes
Other Study ID Numbers: 0049
Study First Received: October 10, 2012
Last Updated: October 29, 2012
Health Authority: Israel: Ministry of Health

ClinicalTrials.gov processed this record on November 20, 2014