Povidone Iodine and Cesarean Section Wound Infections
The aim of this randomized clinical trial is to compare the efficiency of hand scrubbing by Povidone-Iodine solution 10% over 7.5% concentration in decreasing post-cesarean section wound infections & compare side effects of both agents.
Drug: Povidone Iodine 10% vand cesarean section wound infections
Drug: Povidone Iodine 7.5% vand cesarean section wound infections
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
|Official Title:||Povidone Iodine 10% Versus 7.5% Hand Scrub and Cesarean Section Wound Infections: A Randomized Trial|
- The difference of incidence of surgical site infection between both groups [ Time Frame: 4 month ] [ Designated as safety issue: Yes ]Determine the difference in incidence of surgical site infection between Povidone Iodine 10% versus 7.5% hand scrub
- The difference in the side effects between both groups e.g. dermatitis [ Time Frame: 4 month ] [ Designated as safety issue: Yes ]Determine the difference in incidence of side effects between Povidone Iodine 10% versus 7.5% hand scrub
|Study Start Date:||January 2012|
|Study Completion Date:||May 2012|
|Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
Experimental: Povidone Iodine 10%
Using Povidone Iodine 10% hand scrub before caesarian section
|Drug: Povidone Iodine 10% vand cesarean section wound infections|
Experimental: Povidone Iodine 7.5% hand scrub
Using Povidone Iodine 7.5% hand scrub before caesarian section
|Drug: Povidone Iodine 7.5% vand cesarean section wound infections|
For centuries, hand washing with soap and water has been considered the main approach for personal hygiene. In the community, hand hygiene has been known to prevent infectious diseases and to decrease the burden of disease. Currently, hand hygiene is considered the most important measure for preventing the spread of pathogens in health-care settings.
There are multiple agents used for surgical hand scrubbing as alcohol, chlorhexidine, iodine/iodophors, para-chloro-meta-xylenol & triclosan. Ideally, the optimum antiseptic used for scrub should have broad spectrum of activity, persistent effect & fast acting. Unfortunately most studies evaluating surgical scrub antiseptics have focused on measuring hand bacterial colony counts. No randomized clinical trials have evaluated the impact of surgical scrub choice on surgical site infection risk & proven its efficiency.