Anesthetic Requirement and Stress Hormone Response During Surgery in Spinal Cord-injured Patients
Recruitment status was Recruiting
Spinal cord injury (SCI) reduces anesthetic requirements and stress hormonal responses. Anesthetic requirements and stress hormone response are compared in SCI patients undergoing anesthesia with sevoflurane supplemented with clinically equivalent doses of either N2O or remifentanil.
Complete Spinal Cord Injury
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Chonnam National University Hospital IRB|
|Study Start Date:||January 2011|
|Estimated Study Completion Date:||June 2013|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Nitrous oxide (N2O) is often used for anesthetic adjuvant, but may be associated with side effects and toxicities. Remifentanil shares characteristics with N2O, including anesthetic-reducing and antinociceptive effects and a rapid recovery. Anesthetic requirements and stress hormone response in SCI patients undergoing anesthesia with sevoflurane supplemented with clinically equivalent doses of either N2O or remifentanil. Forty-five SCI patients scheduled to undergo pressor sore surgery below the level of the injury are randomly allocated to receive either sevoflurane alone (control, n=15), or combined with 67% N2O (n=15) or target-controlled infusions of 1.37 ng/mL remifentanil (n=15). Sevoflurane concentration is titrated to maintain a Bispectral Index (BIS) value of 40-50. Measurements include end-tidal sevoflurane concentrations, mean arterial blood pressure (MAP), heart rate (HR), and plasma catecholamine and cortisol concentrations.
|Korea, Republic of|
|Department of Anesthesiology and Pain Medicine||Recruiting|
|Gwangju, Korea, Republic of, 501-757|
|Contact: Young W Won 82-62-220-6893 ext 6895 firstname.lastname@example.org|
|Principal Investigator: Kyung Y Yoo, M.D., Ph.D.|