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Pressure Dependent Tracheal Obstruction in Copd Patients (PDTO)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
LHL Helse
ClinicalTrials.gov Identifier:
NCT01679808
First received: September 3, 2012
Last updated: NA
Last verified: September 2012
History: No changes posted
  Purpose

Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study. A garden hose was compressed from one side to simulate the posterior wall of the trachea bulging into the lumen. For two obstruction lengths - 3 cm and 12 cm, the hose was increasingly compressed in eight steps. Resistance was measured at each step for airflows 1 l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a computer to estimate the cross sectional area reduction and the corresponding distance between the bulging (posterior)and the opposite (anterior) wall (AP-distance).

Patient study. 104 stable COPD patients studied by pulmonary function tests and bronchoscopy. The tracheal obstruction was observed during forced expiration and cough, and the cross sectional area reduction was estimated using the results from the model study.


Condition
Tracheobronchomalacia

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Pressure Dependent Tracheal Obstruction in Copd Patients

Further study details as provided by LHL Helse:

Enrollment: 104
Study Start Date: August 2004
Study Completion Date: August 2011
Primary Completion Date: August 2006 (Final data collection date for primary outcome measure)
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients (both sexes) in a pulmonary rehabilitation clinic

Criteria

Inclusion Criteria:

  • copd

Exclusion Criteria:

  • clinical evidence of malignant disease
  • not able to be subjected to bronchoscopy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01679808

Locations
Norway
Glittreklinikken
Hakadal, Akershus, Norway, 1485
Sponsors and Collaborators
LHL Helse
Investigators
Principal Investigator: Ivar Ellingsen, Dr med LHL Helse
  More Information

No publications provided

Responsible Party: LHL Helse
ClinicalTrials.gov Identifier: NCT01679808     History of Changes
Other Study ID Numbers: GK-18, s-04058c
Study First Received: September 3, 2012
Last Updated: September 3, 2012
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by LHL Helse:
copd
airway obstruction
Tracheobronchomalacia

Additional relevant MeSH terms:
Tracheobronchomalacia
Cartilage Diseases
Musculoskeletal Diseases
Bronchial Diseases
Respiratory Tract Diseases
 Tracheal Diseases
Musculoskeletal Abnormalities
Congenital Abnormalities
Connective Tissue Diseases

ClinicalTrials.gov processed this record on June 17, 2013