Investigating Serotonin Signalling in IBD Patients
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in enterochromaffin (EC) cell, main source of 5-HT in the gut, numbers in CD and UC patients. Up-regulated expression of mucosal Tryptophan hydroxylase (TPH)-1, catalytic enzyme in 5-HT production, messenger RNA (mRNA) have been found in CD patients in remission who are suffering the irritable bowel syndrome (IBS)-like symptoms. Alterations in normal 5-HT signaling has also been reported in animal models of inflammatory bowel disease (IBD). Thus, the aim of the proposed research project will be to study the alterations in 5-HT signalling accompanying GI inflammatory conditions, such as IBD.
Inflammatory Bowel Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Investigating Serotonin Signalling in IBD Patients|
- Colonic 5-HT levels [ Time Frame: At the time of tissue collection ] [ Designated as safety issue: No ]
- Receptor expressions [ Time Frame: At the time of tissue collection ] [ Designated as safety issue: No ]
- Colonic cytokine levels [ Time Frame: At the time of tissue collection ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Samples will be collected from inflamed and non-inflamed regions, spanning the distal colon to distal ileum.
|Study Start Date:||July 2012|
|Estimated Study Completion Date:||May 2013|
|Estimated Primary Completion Date:||May 2013 (Final data collection date for primary outcome measure)|
Healthy control group will include participants consenting prior to colorectal cancer screening.
CD patient groups
The patient groups will include patients with clinical diagnosis of CD.
UC patient group
The patient groups will include patients with clinical diagnosis of UC.
|Contact: Zack Muqtadir, CCRA||905-525-9140 ext firstname.lastname@example.org|
|Contact: Md. Sharif Shajib, BSc.||905-525-9140 ext email@example.com|
|McMaster University Medical Center||Recruiting|
|Hamilton, Ontario, Canada, L8S 4K1|
|Principal Investigator:||Waliul I Khan, MBBS, PhD.||Dept. of Pathology & Molecular Medicine, McMaster University, Hamilton, Canada.|
|Principal Investigator:||John Marshall, MD, MSc, FRCPC, AGAF.||Department of Medicine, McMaster University, Hamilton, Canada.|