Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer
PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).
Genetic: RNA analysis
Genetic: proteomic profiling
Other: laboratory biomarker analysis
|Official Title:||Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL|
- Identification and characterization of IncRNA of pediatric T-cell acute lymphoblastic leukemia [ Designated as safety issue: No ]
|Study Start Date:||June 2012|
|Estimated Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
- Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus).
- Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow).
OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.
|Principal Investigator:||Iannis Aifantis, PhD||New York University School of Medicine|