The Utility of Cardiac CT in Excluding Ischemic Cardiomyopathy in Patients With Newly Diagnosed Heart Failure
HF may be classified into two main categories: ischemic, caused by the narrowing of the heart's arteries by cholesterol build up, also called coronary artery disease (CAD) and non-ischemic which is not caused by CAD. The narrowing of the blood vessel may be caused by the build up of calcium deposits. The ability to accurately categorize patients is very important in order to properly manage patients with HF.
The objective of this study is to determine the ability of CT in ruling out ischemic cardiomyopathy as the cause of newly diagnosed heart failure.
We will enroll patients with newly diagnosed heart failure (diagnosed within past 6 months) of unknown etiology. Patients will receive routine investigations (to determine the etiology of heart failure) at the discretion of their attending cardiologist. In addition, patients will undergo a low-dose non-contrast enhanced CT scan. These CT results will be compared to their final clinical diagnosis. An Agatson score of 0 will be used to rule out ischemia as the underlying etiology. The outcome measure will be the ability of CT to rule out ischemia as the cause of heart failure.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Utility of Cardiac CT in Excluding Ischemic Cardiomyopathy in Patients With Newly Diagnosed Heart Failure|
- Coronary artery calcification (Agatston) score [ Time Frame: 3 years ] [ Designated as safety issue: No ]The primary outcomes measure will be coronary artery calcification score (Agatston score = 0 (absence of coronary artery calcification) or Agatston Score > 0 (coronary artery calcification present). The hypothesis of the study is that an Agatston score = 0 rules out CAD as the cause of heart failure.
|Study Start Date:||May 2012|
|Estimated Study Completion Date:||January 2015|
|Estimated Primary Completion Date:||January 2015 (Final data collection date for primary outcome measure)|
Newly diagnosed heart failure patients
Patients with newly diagnose (within 2 months) of congestive heart failure and/or left ventricular dysfunction in whom the etiology of heart failure/LV dysfunction is unknown.
Procedure: CT scan
One CT scan per patient
Please refer to this study by its ClinicalTrials.gov identifier: NCT01622985
|Contact: Benjamin JW Chow, MD, FRCPCfirstname.lastname@example.org|
|University of Ottawa Heart Institute||Recruiting|
|Ottawa, Ontario, Canada, K1Y 4W7|
|Contact: Benjamin JW Chow, MD, FRCPC 613-761-4044 email@example.com|
|Sub-Investigator: Haissam Haddad, MD, FRCPC|
|Sub-Investigator: Lisa Mielniczuk, MD, FRCPC|
|Sub-Investigator: Ronnen Maze, MD|
|Principal Investigator:||Benjamin JW Chow, MD, FRCPC||University of Ottawa Heart Institute|
|Study Chair:||Haissam Haddad, MD, FRCPC||University of Ottawa Heart Institute|
|Study Chair:||Lisa Mielniczuk, MD, FRCPC||University of Ottawa Heart Institute|
|Study Chair:||Ronnen Maze, MD||University of Ottawa Heart Institute|