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Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2013 by Charite University, Berlin, Germany
Sponsor:
Information provided by (Responsible Party):
Jonathan List, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier:
NCT01593956
First received: May 7, 2012
Last updated: May 22, 2013
Last verified: May 2013
  Purpose

Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced. This is possibly due to an increased GABAergic activity, what have been found in concussed athletes by paired pulse protocols in TMS.

GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS.

Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.


Condition Intervention
Concussed Athletes
Healthy Controls
Behavioral: tDCS

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Primary Purpose: Treatment
Official Title: Influence of Anodal Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes and Healthy Volunteers

Further study details as provided by Charite University, Berlin, Germany:

Primary Outcome Measures:
  • Improvement of cortical plasticity after anodal tDCS in concussed athletes

Estimated Enrollment: 30
Study Start Date: March 2012
Estimated Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Concussed athletes Behavioral: tDCS
Healthy controls Behavioral: tDCS

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • history of at least 2 sports concussion
  • age 18 - 50 years

Exclusion Criteria:

  • structural deficit on cerebral MRI
  • Epilepsy
  • neurological disorder
  • intake of CNS-active drugs
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01593956

Locations
Germany
Charité - Department of neurology Recruiting
Berlin, Germany, 10117
Contact: Jonathan List, MD    +40 30 450560223    Jonathan.List@charite.de   
Contact: Agnes Flöel, Prof.    +40 30 450660284    agnes.floeel@charite.de   
Principal Investigator: Jonathan List, MD         
Principal Investigator: Agnes Flöel, Prof         
Sponsors and Collaborators
Charite University, Berlin, Germany
Investigators
Principal Investigator: Jonathan List, MD Charité - Department of Neurology
Principal Investigator: Agnes Flöel, Prof. Charité - Department of Neurology