Vitamin D, Magnesium and Calcium in Chronic Obstructive Pulmonary Disease (COPD)
This study will investigate the serum level of vitamin D, magnesium and calcium in patients with chronic obstructive pulmonary disease (COPD) in order to evaluate the impact of vitamin D, magnesium and calcium on lung function in COPD-patients.
Chronic Obstructive Pulmonary Disease (COPD)
|Study Design:||Time Perspective: Cross-Sectional|
|Official Title:||Vitamin D, Magnesium And Calcium In Chronic Obstructive Pulmonary Disease (COPD)|
- Vitamin D [ Time Frame: one year ] [ Designated as safety issue: No ]vitamin D measured by p-25-hydroxy-vitamin D2 + D3
- Lung function test [ Time Frame: one year ] [ Designated as safety issue: No ]FEV1, FVC, FEF25-75
Biospecimen Retention: Samples Without DNA
p-creatinine p-potassium p-sodium p-albumine p-phosphate p-magnesium p-calcium-ion p-parathyrine p-25-hydroxy-vitamin D2 + D3
|Study Start Date:||February 2012|
|Study Completion Date:||January 2013|
|Primary Completion Date:||October 2012 (Final data collection date for primary outcome measure)|
Attention is enhancing worldwide on the increasing tendency of insufficient 25-hydroxyvitamin D serum levels. New insights into the role of vitamin D and distribution of its receptors in the human body have been revealed. Presumably, this entails implications concerning disease and treatment that go far beyond the well-known field of bone-metabolism.
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), and reductions in vitamin D serum levels have formerly been perceived as a consequence rather than a cause of COPD.
Yet, there is a lack of consensus concerning the role of vitamin D on the decreasing lung function in COPD.
Some trials have revealed a high degree of co-variation between the grade of airway obstruction, intake of vitamin D and reduction of serum-vitamin D. Other claim that vitamin D appears to be capable of inhibiting pulmonary inflammatory responses.
Vitamin D interacts with calcium and magnesium and this subtle balance might be highly relevant in the progression of inflammatory diseases like COPD. Presumably, Mg inhibits contraction and relaxes smooth muscles in airways due to blocking of calcium-ion-flux across the cell membrane.
The aim of this study is to investigate the status of vitamin D, magnesium and calcium in COPD, and to study the relationship and impact of vitamin D, magnesium and calcium in COPD-patients.
The hypothesis of this study is that COPD-patients with vitamin D-, magnesium- and calcium supplement have a better lung function and quality of life, than those who have vitamin D-, magnesium- and calcium deficiency.
|Aarhus University Hospital|
|Aarhus, Denmark, 8210|
|Study Director:||Ronald Dahl, Professor||Department of Respiratory Diseases, Aarhus University Hospital|
|Principal Investigator:||Sarah Hashim Ali Hussein, Student||Department of Respiratory Diseases, Aarhus University Hospital|