Studying Biomarkers as a Diagnostic Tool in Samples From Younger Patients With B-Cell Acute Lymphoblastic Leukemia
RATIONALE: Finding specific biomarkers may help improve the treatment of patients with B-cell acute lymphoblastic leukemia.
PURPOSE: This clinical trial is studying biomarkers as a diagnostic tool in samples from younger patients with B-cell acute lymphoblastic leukemia.
Genetic: fluorescence in situ hybridization
Genetic: microarray analysis
Other: diagnostic laboratory biomarker analysis
Other: flow cytometry
Other: laboratory biomarker analysis
|Study Design:||Primary Purpose: Diagnostic|
|Official Title:||Replication Profiling as a Diagnostic Tool in B-cell Acute Lymphoblastic Leukemia (ALL)|
- Replication-timing changes as a biomarker for further risk prediction [ Designated as safety issue: No ]
|Study Start Date:||February 2012|
|Estimated Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
- To determine whether we can identify individuals within a specific sub-group of pre-B acute lymphoblastic leukemia (ALL) patients that will eventually recur.
- To identify replication-timing changes as a biomarker for further risk prediction.
- To identify differences between patients of similar subtype, and choose candidate differences to analyze by methods that are compatible with frozen samples.
OUTLINE: Archived cell samples are analyzed for replication timing by flow cytometry, microarray, and single-cell fluorescence in situ hybridization (FISH) assays. Replication-timing results among cases and controls are also analyzed.
|Principal Investigator:||David M. Gilbert, MD||Florida State University|