Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Danilo Marcelo Leite do Prado, Hospital TotalCor
ClinicalTrials.gov Identifier:
NCT01515033
First received: January 18, 2012
Last updated: January 20, 2012
Last verified: January 2012
  Purpose

The purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (PETCO2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among PETCO2 at ventilatory anaerobic threshold (VAT) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.


Condition Intervention Phase
Coronary Artery Disease
Exercise Addiction
Complication, Cardio-respiratory
Other: aerobic exercise training
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effect of Continuous and Interval Exercise Training on PETCO2 Response During Graded Exercise Test in Patients With Coronary Artery Disease

Resource links provided by NLM:


Further study details as provided by Hospital TotalCor:

Primary Outcome Measures:
  • PetCO2 response during graded exercise test [ Time Frame: before and after 3 months of the interventions ] [ Designated as safety issue: Yes ]
    End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation


Enrollment: 37
Study Start Date: September 2010
Study Completion Date: August 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Continuous exercise training
The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
Other: aerobic exercise training

The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.

The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

Other Names:
  • continuous training
  • interval training
Experimental: interval exercise training
The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
Other: aerobic exercise training

The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.

The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

Other Names:
  • continuous training
  • interval training

Detailed Description:

End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions. Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation. In this regard, it has been shown that patients with cardiac disease have an abnormally low PETCO2 during exercise, especially those with an impaired response of cardiac output during exercise

  Eligibility

Ages Eligible for Study:   40 Years to 79 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria:

  • unstable angina pectoris,
  • complex ventricular arrhythmias,
  • pulmonary congestion and
  • orthopaedic or neurological limitations to exercise
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01515033

Sponsors and Collaborators
Hospital TotalCor
Investigators
Principal Investigator: Danilo ML Prado, Prof.MS Hospital TotalCor
  More Information

No publications provided

Responsible Party: Danilo Marcelo Leite do Prado, MS, Hospital TotalCor
ClinicalTrials.gov Identifier: NCT01515033     History of Changes
Other Study ID Numbers: 117/11
Study First Received: January 18, 2012
Last Updated: January 20, 2012
Health Authority: Brazil: Ethics Committee

Keywords provided by Hospital TotalCor:
Coronary artery disease
Exercise
Ventilatory efficiency

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on September 16, 2014