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Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01493128
First received: December 13, 2011
Last updated: December 14, 2011
Last verified: December 2011
History of Changes
  Purpose

The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since there exist no current information on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF) the investigators sought to determine whether a regulation of these proteins may be an underlying cause of the disease. Mitochondrial function will also studied.

  1. The investigators hypothesize that structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared to patients in sinus rhythm.
  2. The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared to patients in sinus rhythm.

Condition
Atrial Fibrillation

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Biospecimen Retention:   Samples Without DNA

Myocardial tissue from the right and left atrial appendage.


Estimated Enrollment: 45
Study Start Date: April 2010
Estimated Study Completion Date: February 2012
Estimated Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
stable sinus rhythm
permanent atrial fibrillation
paroxysmal atrial fibrillation

  Eligibility

Ages Eligible for Study:   50 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Samples were obtained with written informed consent from the right and left atrial appendage, during open heart surgery from patients in sinus rhythm, with permanent AF and paroxysmal AF.

Criteria

Inclusion Criteria:

  • sinus rhythm, permanent atrial fibrillation or paroxysmal atrial fibrillation
  • selected for open heart surgery

Exclusion Criteria:

  • not given informed consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01493128

Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Study Director: Ulrik Wisløff, PhD Norwegian University of Science and Technology
  More Information

No publications provided

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01493128     History of Changes
Other Study ID Numbers: ABJ01
Study First Received: December 13, 2011
Last Updated: December 14, 2011
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Norwegian University of Science and Technology:
atrial fibrillation
atrial cells
myocardial tissue
t-tubules
immunofluorescence

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on May 19, 2013