Correlates of Oral Human Papillomavirus Infection in Adolescents and Young Adults With Behaviorally Acquired HIV

• Prevalence of HPV infection, outcome defined as HPV positive or HPV negative [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  Beta-globin positive samples (reported as Positive/negative; there is no unit of measure) will be considered evaluable and classified as HPV-positive if any of the 37 HPV DNA types were detected) and HPV negative if all HPV types were negative.
  
  

• Behavioral Factors [ Time Frame: 1 year ] [ Designated as safety issue: No ]

  Sexual behaviors:

  • Sexual encounters for male/female: type of sexual contact/in the last 3 months N number of partners by type of sexual contact/in last 3 months

  Substance use behaviors:

  • Tobacco product use (ever used, frequency of use past 3 months); <= 1/month >=1/=week
  • Alcohol use (ever used, frequency of use past 3 months); Irregular/regular
  • Marijuana use (ever used, frequency of use past 3 months); <= 1/month >=1/=week
  • Cocaine use ((ever used, frequency of use past 3 months); <= 1/month >=1/=
  
  
• Immunologic factors [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  The immunological factors will include CD4+ cell count (cell/uL) and severity of disease according to the CDC Staging/Immunologic Category for HIV Disease (No unit of measurements)
  
  
• Virologic factors [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  HIV viral load (copies/ml), EBV [(copies of EBV PHC( per human cells)] and KSHV (HHV-8) [copies of HHV-8 PHC (per human cells)]
  
  

ATN 114 is a cross-sectional substudy of ATN 106. In addition to sharing data collected in ATN 106, an oral rinse sample along with the subject's self reported history and medical chart abstraction of HPV vaccination status and medical chart abstraction of a history of oral condylomata, oral dysplasia and oral tumor viruses will be collected in ATN 114.

Recruitment is expected to last approximately one year, similar to the same timeframe for ATN 106. Enrollment may be terminated earlier at the discretion of the ATN Executive Committee and/or the ATN 114 protocol team should ATN 106 also terminate enrollment early. Individuals who have agreed to participate in ATN 106 may be simultaneously approached at any clinic visit, or, for community-based sites, contacted directly for participation in ATN 114. Site staff may also contact individuals via phone, e-mail, or any other agreed-upon methods of communication. Site staff should try as much as possible to incorporate the study visit into a regularly scheduled clinic visit.