MRA/fMRI Study of Spontaneous Migraine

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2012 by Glostrup University Hospital, Copenhagen.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Leiden University Medical Center
Information provided by (Responsible Party):
Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen
ClinicalTrials.gov Identifier:
NCT01471314
First received: November 10, 2011
Last updated: August 28, 2012
Last verified: August 2012
  Purpose

The purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (MRI), to study following:

  • Changes in resting state blood-oxygenation-level-dependent-signal (BOLD-signal) using functional MRI (fMRI).
  • Changes in circumferences of intra- and extracranial arteries using MR-angiography (MRA).
  • Changes in regional and global cerebral blood flow (CBF) using the arterial spin labeling (ASL) method.

Moreover to perform diffusion tensor imaging (DTI) scans during spontaneous migraine attacks.

The migraine specific drug sumatriptan will be given to relieve pain and the effect will be registered using MRA and fMRI if possible.


Condition Intervention
Headache Versus Non-headache Day
Behavioral: Headache day versus non-headache day

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Functional MRI and MR Angiography Used in Spontaneous Migraine

Resource links provided by NLM:


Further study details as provided by Glostrup University Hospital, Copenhagen:

Groups/Cohorts Assigned Interventions
Spontaneous migraine Behavioral: Headache day versus non-headache day

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Migraine without aura

Criteria

Inclusion Criteria:

  • Migraine without aura according to IHS criteria.

Exclusion Criteria:

  • Other primary headaches.
  • Tension-type headache more than 5 days/month.
  • Use of anti-pain medication before the scanning on the examination day.
  • Pregnant or nursing women.
  • Contraindication for MR scan.
  • Anamnestic or clinical signs of cardiovascular or cerebrovascular disease, unregulated psychiatric disease or drug misuse.
  • Other clinical conditions assessed by the examining doctor.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01471314

Contacts
Contact: Faisal Amin, MD, PhD student +4538633066 famoam01@regionh.dk

Locations
Denmark
Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen Recruiting
Glostrup, Denmark, DK-2600
Contact: Faisal Amin, MD, PhD student    +4538633066    famoam01@regionh.dk   
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Leiden University Medical Center
  More Information

No publications provided by Glostrup University Hospital, Copenhagen

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Faisal Mohammad Amin, MD, PhD student, Glostrup University Hospital, Copenhagen
ClinicalTrials.gov Identifier: NCT01471314     History of Changes
Other Study ID Numbers: H-C-2008-089
Study First Received: November 10, 2011
Last Updated: August 28, 2012
Health Authority: Denmark: The Danish National Committee on Biomedical Research Ethics

ClinicalTrials.gov processed this record on October 19, 2014