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Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Humberto Nicastro, University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT01350427
First received: May 2, 2011
Last updated: February 22, 2013
Last verified: February 2013
History of Changes
  Purpose

This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.


Condition Intervention
Healthy
 Dietary Supplement: Leucine supplementation
Dietary Supplement: BCAA supplementation
Dietary Supplement: Alanine supplementation

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • Protein synthesis [ Time Frame: 1 hour ] [ Designated as safety issue: Yes ]
    Phosphorylation of proteins involved in protein synthesis

  • Protein degradation [ Time Frame: 1 hour ] [ Designated as safety issue: Yes ]
    Expression of protein involved in proteolytic pathway

  • Inflammation [ Time Frame: 1 hour ] [ Designated as safety issue: Yes ]
    Expression of systemic and muscular cytokines


Enrollment: 18
Study Start Date: August 2011
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Leucine Dietary Supplement: Leucine supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine
Experimental: BCAA Dietary Supplement: BCAA supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine
Placebo Comparator: Placebo Dietary Supplement: Alanine supplementation
1 bout of resistance exercise and supplementation of 9.6 g of alanine

  Eligibility

Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Sedentaries
  • Must be able to exercise
  • Must be able to swallow tablets

Exclusion Criteria:

  • Use of nutritional supplements
  • Use of anti-inflammatory drugs
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01350427

Locations
Brazil
University of São Paulo - School of Physical Education and Sports
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
Investigators
Principal Investigator: Claudia R da Luz, Master Student University of São Paulo
  More Information

No publications provided

Responsible Party: Humberto Nicastro, PhD, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT01350427     History of Changes
Other Study ID Numbers: 2011/04690-6
Study First Received: May 2, 2011
Last Updated: February 22, 2013
Health Authority: Brazil: Ethics Committee

Keywords provided by University of Sao Paulo:
leucine supplementation
BCCA supplementation
resistance exercise-induced muscle remodeling

ClinicalTrials.gov processed this record on May 16, 2013