Acute Cardiovascular Effects of Cigarette Smoking

This study has been completed.
Sponsor:
Information provided by:
Andhra Medical College
ClinicalTrials.gov Identifier:
NCT01346956
First received: May 2, 2011
Last updated: May 3, 2011
Last verified: January 2003
  Purpose

Twenty healthy smokers will be subjected to measurement of Pulse, Blood Pressure, electrocardiogram (ECG) and Echo at baseline and after smoking a cigarette. The measurements will be compare for any cardiovascular effects of a cigarette smoking on these parameters.


Condition
Smoking

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Acute Cardiovascular Effects of Cigarette Smoking

Resource links provided by NLM:


Further study details as provided by Andhra Medical College:

Enrollment: 20
Study Start Date: July 2002
Study Completion Date: August 2002
Primary Completion Date: August 2002 (Final data collection date for primary outcome measure)
Detailed Description:

Twenty male persons habituated to smoking (at least 5 cigarettes/day) will be recruited after an informed consent. Healthy persons with no systemic illness will be included. After a history and a routine examination, subjects will be asked to abstain from smoking for 3 hours and then their pulse, BP, ECG and echo recorded. The measurements will be repeated after 15 min. and the average of these two taken as baseline readings. Then, they will be asked to smoke a cigarette and the measurements taken again. Special focus will be on Doppler measures of left ventricular (LV) function. The measurements are repeated immediately and at 5,10 and 15 min. The data will be analyzed for any cardiovascular effects of smoking a cigarette. Chi square test for proportions and t-test for means will be done. A p value < 0.05 will be taken as significant.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Twenty healthy male smokers

Criteria

Inclusion Criteria:

  • Healthy male smokers (at least 5 cigarettes /day) >18 years old.

Exclusion Criteria:

  • Any cardiac or respiratory or systemic illness,including hypertension.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01346956

Locations
India
Andhra Medical College
Visakhapatnam, Andhra Pradesh, India, 530002
Sponsors and Collaborators
Andhra Medical College
Investigators
Principal Investigator: Venkatachelam R Chitrapu, MD DM Andhra Medical College
  More Information

No publications provided

Responsible Party: Ravi Venkatachelam Chitrapu, Andhra Medical College
ClinicalTrials.gov Identifier: NCT01346956     History of Changes
Other Study ID Numbers: 02AMCRAVSAND07
Study First Received: May 2, 2011
Last Updated: May 3, 2011
Health Authority: India: Drugs Controller General of India

Keywords provided by Andhra Medical College:
Cigarette
Smoking
Cardiovascular Effects
2D Echocardiography
Doppler

ClinicalTrials.gov processed this record on October 23, 2014