Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Chondrosarcoma

Inclusion Criteria:

• Written informed consent
• Age > or = to 18 years
• Histologically confirmed diagnosis of conventional chondrosarcoma of any grade
• Surgically unresectable or metastatic disease
• Any number of prior treatment regimens, including treatment naive subjects
• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
• Measurable or evaluable (non-measurable) disease per RECIST guidelines version 1.1
• Adequate organ system function determined within 14 days prior to first dose of study treatment
• Females must either be of non-child bearing potential or have a negative serum pregnancy test within 7 days prior to the first dose of study treatment

Exclusion Criteria:

• Mesenchymal, dedifferentiated, and extraskeletal myxoid chondrosarcoma subtypes
• Prior malignancy (Note: subjects who have had another malignancy and have been disease-free for 3 years, or subjects with a history of completely resected non-melanomatous skin carcinoma or successfully treated in situ carcinoma are eligible)
• History or clinical evidence of central nervous system metastases or leptomeningeal carcinomatosis
• Clinically significant gastrointestinal (GI) abnormalities that may increase the risk for GI bleeding
• Clinically significant GI abnormalities that may affect absorption of investigational product
• Presence of uncontrolled infection
• Corrected QT interval > 480 msecs using Bazett's formula
• History of certain cardiovascular conditions within the past 6 months
• Poorly controlled hypertension [defined as systolic blood pressure of > or = 140 mmHg or diastolic blood pressure of > or = 90 mmHg]
• History of cerebrovascular accident including transient ischemic attack, pulmonary embolism, or untreated deep venous thrombosis within the past 6 months
• Prior major surgery or trauma within 28 days prior to the first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer
• Evidence of active bleeding or bleeding diathesis
• Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels
• Hemoptysis in excess of 2.5 mL within 8 weeks of first dose of study drug
• Any serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with subject's safety, provision of informed consent, or compliance to study procedures
• Unable or unwilling to discontinue use of prohibited medications for at least 14 days prior to the first dose of study drug and for the duration of study treatment
• Radiation therapy, surgery (except major surgery), tumor embolization, chemotherapy, immunotherapy, biologic therapy, investigational therapy, or hormonal therapy within 14 days prior to the first dose of study drug
• Any ongoing toxicity from prior anti-cancer therapy that is > Grade 1 and/or that is progressing in severity, except alopecia