Accommodation Disorders (AD)

This study is enrolling participants by invitation only.
Sponsor:
Collaborator:
Southern California College of Optometry
Information provided by (Responsible Party):
Christopher Chase, Western University of Health Sciences
ClinicalTrials.gov Identifier:
NCT01329848
First received: April 4, 2011
Last updated: May 17, 2012
Last verified: May 2012
  Purpose

This project will develop clinically useful, objective measurements of accommodative insufficiency and fatigue using continuous autorefraction recordings. The development of these procedures will help vision care professionals diagnose and treat accommodative anomalies.


Condition
Accommodative Insufficiency
Ill-sustained Accommodation

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Using Accommodative Lag to Diagnose Accommodation Disorders

Further study details as provided by Western University of Health Sciences:

Primary Outcome Measures:
  • Accommodation lag [ Time Frame: 3 week period ] [ Designated as safety issue: No ]
    Lag will be measured at different viewing distances and durations using autorefraction.


Secondary Outcome Measures:
  • Severity of visual discomfort symptoms assessed by self-report questionnaires. [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
    Conlon visual discomfort survey, CISS survey, and Pattern Glare test.


Estimated Enrollment: 120
Study Start Date: December 2010
Estimated Study Completion Date: August 2013
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
High discomfort symptoms
Subjects who report a high level of discomfort symptoms while performing near work
Low discomfort symptoms
Subject who report low levels of discomfort while performing near work

Detailed Description:

This project studies accommodative function, the ability to focus while doing near work. Visual discomfort symptoms, such as headaches, sore eyes, and blurred vision are commonly associated with prolonged reading or other near work. Researchers have long suspected accommodative dysfunction was involved but most clinical studies have failed to establish a relationship between weak accommodation and symptoms or reading impairments. Recent research, however, has found that clinical measure overestimate accommodative function and encourage the use of objective, autorefraction methods to measure and study accommodative weakness. This project will accomplish three goals. First, using autorefraction objective reliable procedures will be developed for measuring accommodative lag, the difference between the target location and where the eye is focused. Second, experiments will measure in real-time the impact of accommodative lag on reading fluency and visual discomfort systems. Third, studies will explore the role of the slow adaptive component in accommodative weakness. This work will lead to better methods for diagnosing and treating accommodative disorders.

  Eligibility

Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Graduate students from Western University of Health Sciences

Criteria

Inclusion Criteria:

  • older adolescent and young adult
  • skilled readers who attend school
  • are skilled readers
  • have heavy reading demands

Exclusion Criteria:

  • Age > 30.
  • Abnormal vergence system.
  • Dry-eye.
  • Uncorrected visual defects or significant ocular pathology.
  • Learning disability or low IQ
  • Medical conditions that might cause uncomfortable visual symptoms (e.g., migraine headaches, epilepsy, head trauma); sensory defects (e.g., deafness), or neurological conditions (e.g., stuttering) that could impair reading development or oral reading fluency.
  • Somatosensory amplification.
  • Systemic illness or medication associated with accommodative dysfunction.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01329848

Locations
United States, California
Western University of Health Sciences
Pomona, California, United States, 91766
Sponsors and Collaborators
Western University of Health Sciences
Southern California College of Optometry
Investigators
Principal Investigator: Chris Chase, PhD Western University of Health Sciences
  More Information

No publications provided

Responsible Party: Christopher Chase, Professor of Optometry, Western University of Health Sciences
ClinicalTrials.gov Identifier: NCT01329848     History of Changes
Other Study ID Numbers: 1R15EY021021
Study First Received: April 4, 2011
Last Updated: May 17, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Western University of Health Sciences:
Accommodation
Reading
Autorefraction

Additional relevant MeSH terms:
Presbyopia
Ophthalmoplegia
Spasm
Refractive Errors
Eye Diseases
Ocular Motility Disorders
Cranial Nerve Diseases
Nervous System Diseases
Paralysis
Neurologic Manifestations
Signs and Symptoms
Neuromuscular Manifestations

ClinicalTrials.gov processed this record on July 24, 2014