Angina in Non Coronary Artery Disease (HeartQuest)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Prof. Paul Erne, Luzerner Kantonsspital
ClinicalTrials.gov Identifier:
NCT01318629
First received: March 17, 2011
Last updated: April 16, 2013
Last verified: April 2013
  Purpose

Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.


Condition
Angina Pectoris
Microvascular Angina
Angina Pectoris, Variant

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study

Resource links provided by NLM:


Further study details as provided by Luzerner Kantonsspital:

Primary Outcome Measures:
  • Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: One day ] [ Designated as safety issue: No ]
  • Prognosis of patients with angina equivalent symptoms and normal coronary arteries [ Time Frame: 10 years after baseline assessment ] [ Designated as safety issue: No ]

Enrollment: 718
Study Start Date: July 1996
Estimated Study Completion Date: July 2018
Estimated Primary Completion Date: July 2018 (Final data collection date for primary outcome measure)
Detailed Description:

All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study.

Criteria

Inclusion Criteria:

  • Coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008
  • No significant coronary stenoses (no coronary stenoses ≥ 50%)

Exclusion Criteria:

  • Severe valvular heart disease
  • Severe congestive heart failure
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01318629

Locations
Switzerland
Luzerner Kantonsspital
Luzern, Switzerland, 6000
Sponsors and Collaborators
Luzerner Kantonsspital
Investigators
Principal Investigator: Paul Erne, MD Luzerner Kantonsspital
  More Information

No publications provided by Luzerner Kantonsspital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof. Paul Erne, Luzerner Kantonsspital
ClinicalTrials.gov Identifier: NCT01318629     History of Changes
Other Study ID Numbers: Heart Quest
Study First Received: March 17, 2011
Last Updated: April 16, 2013
Health Authority: Switzerland: Ethikkommission

Additional relevant MeSH terms:
Angina Pectoris
Angina Pectoris, Variant
Coronary Artery Disease
Microvascular Angina
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Chest Pain
Pain
Signs and Symptoms
Angina, Unstable
Coronary Disease
Arteriosclerosis
Arterial Occlusive Diseases

ClinicalTrials.gov processed this record on August 21, 2014