ClinicalTrials.gov processed this data on June 17, 2013 Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT01293786 03-02-2011 NCT01293786 Serum Magnesium and Vascular Calcification Comparison of Vascular Calcification Between Kidney Transplant Recipients and Predialysis Chronic Kidney Disease and Its Association With Serum Magnesium Ramathibodi Hospital Other Ramathibodi Hospital Thailand: Mahidol University No Both Kidney transplantation (KT) and Chronic Kidney Disease (CKD) patients have reduced kidney function. Low serum magnesium is more prevalent in KT recipients. The present study examines the difference in vascular calcification between KT and CKD and its association with serum magnesium. Kidney transplantation (KT) improved quality of life and longevity of CKD patients. Nevertheless, kidney function deteriorates overtime in a manner not different from CKD counterparts. Hypomagnesemia is prevalent in KT recipients secondary to immunosuppressive therapy. In addition to serum calcium, phosphate and elemental calcium intake, the relationship between low serum magnesium and vascular calcification (VC) has been observed in small studies in CKD. Whether low serum magnesium associates with VC in KT has never been elucidated. The present study compares vascular calcification between KT and CKD and its association with serum magnesium. Completed February 2011 May 2011 May 2011 N/A Observational Observational Model: Case Control, Time Perspective: Cross-Sectional The difference in vascular calcification score between KT and CKD Baseline No The association of serum magnesium with vascular calcification in KT Baseline No The association of serum magnesium with vascular calcification in CKD Baseline No 2 400 Vascular Calcification Chronic Kidney Disease Kidney transplant recipients Chronic kidney disease Samples Without DNA serum Kidney transplant recipients and predialysis chronic kidney disease patients from outpatient nephrology clinic of Ramathibodi hospital, Mahidol University Probability Sample Inclusion Criteria: - kidney transplant recipients at least 1 year post surgery - predialysis chronic kidney disease with serum creatinine > 1.1 mg/dL in female and 1.3 mg/dL in male Exclusion Criteria: - acute kidney injury - parathyroidectomy Both 18 Years N/A No Sinee Disthabanchong, MD Principal Investigator Ramathibodi Hospital, Mahidol University Faculty of Medicine, Ramathibodi Hospital, Mahidol University

Phayathai Bangkok 10400 Thailand

Thailand May 2011 May 25, 2011 February 10, 2011 Sinee Disthabanchong, MD Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand magnesium kidney transplantation hypomagnesemia No No Calcinosis Kidney Diseases Renal Insufficiency, Chronic Kidney Failure, Chronic