The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis

This study has been completed.
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01285336
First received: January 26, 2011
Last updated: January 27, 2011
Last verified: January 2012
  Purpose

This study is valuable for the understanding the role of DNA repair system plays in the progression of rheumatoid arthritis and for the development of new therapeutic modality in the future.


Condition
Rheumatoid Arthritis

Study Type: Interventional
Study Design: Primary Purpose: Health Services Research
Official Title: The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis.

Resource links provided by NLM:


Further study details as provided by China Medical University Hospital:

Study Start Date: August 2010
Arms
Experimental: The genetic and the functional study

Detailed Description:

Rheumatoid arthritis (RA) is a symmetric polyarticular arthritis that primarily affects the small diarthrodial joints of the hands and feet. In addition to inflammation in the synovium, which is the joint lining, the aggressive front of tissue called pannus invades and destroys local articular structures. The synovium is normally a relatively acellular structure with a delicate intimal lining. RA is also a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. It is known that RA can be considered as a complex genetic disease and many "disease-risk" genes or "disease-protective" genes can be involved. Numerous studies reported the association of IL-6, IL-8 genes with systemic lupus erythematosus (SLE) and the association of HLA-DR gene polymorphisms with RA. In addition, the chronic inflammatory process of RA is mediated through cytokines network, which leads to induce some destructive enzymes, like matrix metalloprotieases, in the cellular synovial tissue of joints. Although RA is a common arthritis with a prevalence of 1% in Taiwan, the pathogenesis is still incompletely studied, especially in DNA repair relative genes.

In this proposal, we would like to perform the following experiments:

  1. Study the associations of the polymorphisms of DNA repair relative genes and the susceptibility to RA;
  2. Study the associations of the copy number variation (CNV) of DNA repair relative genes and the susceptibility to RA;
  3. Functional assay in DNA repair relative genes and compare it with the copy number variation (CNV), genotype and/or haplotype in RA patients; So far, we have analyzed the association between RA and several SNPs of MUTYH in DNA repair systems. We also analyzed the relationship between the SNPs results and RA using the pathological features. These data are helpful to clarify the susceptibility of RA patients with the genotype and/or haplotype in DNA repair system.

This study is valuable for the understanding the role of DNA repair system plays in the progression of rheumatoid arthritis and for the development of new therapeutic modality in the future.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Participant has sang a consent form.

Exclusion Criteria:

  • Participant is under 18 years old.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01285336

Locations
Taiwan
The Institutional Review Board China Medical University Hospital
Taichung, Taiwan
Sponsors and Collaborators
China Medical University Hospital
National Science Council, Taiwan
  More Information

No publications provided

Responsible Party: Chung-Ming Huang, China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01285336     History of Changes
Other Study ID Numbers: DMR98-IRB-309-1, NSC99-2314-B-039-005-MY3
Study First Received: January 26, 2011
Last Updated: January 27, 2011
Health Authority: Taiwan: Institutional Review Board

Keywords provided by China Medical University Hospital:
Rheumatoid arthritis (RA)
DNA repair system
polymorphism
susceptibility
copy number variation (CNV)

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Disease Susceptibility
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on August 19, 2014