Labour Analgesia and Movement in Babies (LAMB)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of British Columbia
ClinicalTrials.gov Identifier:
NCT01280084
First received: January 18, 2011
Last updated: February 10, 2012
Last verified: February 2012
  Purpose

This study aims to measure movements in babies after they are born using an actigraph, a wristwatch-sized device worn on the ankle, which works similarly to the device used by runners to count the number of steps they have taken. We aim to compare the movements of babies whose mothers have received different types of pain relief in labour.


Condition
Labour Analgesia and Neonate Activity

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Effect of Labour Analgesia on Babies' Movements After Birth: An Actigraphic Study

Resource links provided by NLM:


Further study details as provided by University of British Columbia:

Primary Outcome Measures:
  • Neonates' mobile and immobile time in 24 hours [ Time Frame: Within the first 24 hours of life ] [ Designated as safety issue: No ]
  • Neonates' number of mobile and immobile bouts in 24 hours [ Time Frame: Within the first 24 hours of life ] [ Designated as safety issue: No ]
  • Total activity score [ Time Frame: Within the first 24 hours of life ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Neonates' total sleep time in 24 hours, night-time sleep in 24 hours and day-time sleep in 24 hours [ Time Frame: Within the first 24 hours of life ] [ Designated as safety issue: No ]
  • Neonates' total number of sleep bouts [ Time Frame: Within the first 24 hours of life ] [ Designated as safety issue: No ]

Enrollment: 40
Study Start Date: February 2011
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
No labour analgesia/nitrous oxide
Women who use no analgesia during labour or who only used nitrous oxide.
Systemic opioids
Women who receive only systemic opioids for analgesia during, either intravenously or intramuscularly
Intermediate dose epidural fentanyl
Women who receive a total epidural fentanyl dose less than 150 micrograms
High dose epidural fentanyl
Women who receive a total epidural fentanyl dose more than 150 micrograms

Detailed Description:

The purpose of the study is to investigate the potential utility of actigraphy, a non-invasive means of measuring an individual's movements, in distinguishing the effects of different types of maternal labour analgesia on babies after birth.

The study hypothesizes that actigraphic data can be used to differentiate the effects on neonates of different forms of maternal intrapartum analgesia. In particular, we hypothesize that infants of mothers who receive intrapartum opioid analgesia will demonstrate fewer movements than infants of mothers who receive epidural analgesia or those who receive nothing.

Whilst it is well known that drugs administered to mothers during labour can affect their babies, means of assessing this effect are complex and unreliable. A more objective means of assessing babies after birth is required, and actigraphy may represent a useful technique. Actigraphy has been used on babies in other studies in a variety of settings, including comparing babies born by different delivery modes (i.e. vaginal versus cesarean delivery) and at different gestations (i.e. term versus preterm), although none of these studies have considered maternal analgesia received prior to delivery as a possible influence on babies' movements after birth. Other studies that have looked at sleep parameters in babies, particularly measures of activity, have shown association with later indices of psychomotor development.

The objective of the study is to compare actigraph-derived movement data from babies whose mothers have received any of the commonly used analgesic techniques for labour at BC Women's Hospital.

This is a prospective observational study. Women will be assessed for eligibility for the study on admission to the labour ward. As one of the inclusion criteria is vaginal birth, women considered eligible on admission may become ineligible depending on their mode fo delivery. Information will be available to all women in the assessment rooms and consent will be specifically sought after they deliver and are deemed eligible. We plan to recruit the babies of mothers who receive analgesia in one of four categories: no analgesia or nitrous oxide only; systemically administered opioid analgesia only; epidural analgesia with an intermediate total dose of fentanyl (<150mcg); epidural analgesia with a high total dose of fentanyl (>150mcg). We recognize that women may receive several or even all of the different modalities of labour analgesia in the course of their delivery. In this situation, we will calculate the total dose fo opioid received by all routes and convert this to fentanyl equivalents for the purposes of analysis. Neonates of women who agree to participate will be fitted with an actigraph that will remain in place (except for removal for bathing) for 24 hours, or until discharge from hospital. Actigraphs are small, light-weight, wrist-watch-sized monitors that weight 16 grams. The actigraphs will be placed on the neonates' ankle, as this position has been reported to cause less disturbance to them. Parents of participating neonates will also be instructed in the use fo a daily dairy that will allow correlation of actigraphic movement data with events such as bathing (when the actigraph will necessarily be removed) and other external sources of movements (e.g. being rocked, breastfeeding).

  Eligibility

Ages Eligible for Study:   19 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Healthy women who have vaginal deliveries at BC Women's Hospital

Criteria

Inclusion Criteria:

  • Neonates born to healthy women with singleton pregnancies who deliver vaginally at term gestation (> 37 weeks)
  • Mothers aged 19 years or older and understand written and oral English
  • Neonates who are neurologically healthy

Exclusion Criteria:

  • Cesarean delivery; patients booked for cesarean delivery presenting in labour
  • Maternal opioid dependence
  • Maternal sedative or psychotropic medications
  • Maternal combined spinal epidural (CSE) analgesia in labour
  • Forceps delivery; 4th degree perineal tears
  • Birth weight greater than 4.5 kg
  • Intrapartum fetal heart rate abnormalities requiring immediate delivery
  • Neonates of mothers who receive epidural morphine for post-delivery analgesia
  • Neonates requiring admission to NICU
  • Neonates with obvious congenital anomalies
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01280084

Locations
Canada, British Columbia
British Columbia Women's Hospital
Vancouver, British Columbia, Canada, V6H 3N1
Sponsors and Collaborators
University of British Columbia
Investigators
Principal Investigator: Naomi Kronitz, MD, FRCPC Department of Anesthesia, BC Women's Hospital
  More Information

No publications provided

Responsible Party: University of British Columbia
ClinicalTrials.gov Identifier: NCT01280084     History of Changes
Other Study ID Numbers: H10-02900
Study First Received: January 18, 2011
Last Updated: February 10, 2012
Health Authority: Canada: Health Canada

Keywords provided by University of British Columbia:
neonate activity
labour analgesia

Additional relevant MeSH terms:
Nitrous Oxide
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents

ClinicalTrials.gov processed this record on August 26, 2014