LOC387715/HTRA1 and the Combined Photodynamic Therapy With Intravitreal Bevacizumab in Polypoidal Choroidal Vasculopathy
This study is to investigate whether there is an association of the LOC387715/HTRA1 variants with response to treatment with combined photodynamic therapy and intravitreal bevacizumab for patients with polypoidal choroidal vasculopathy.
Age-Related Macular Degeneration
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||LOC387715/HTRA1 Variants and the Response to Combined Photodynamic Therapy With Intravitreal Bevacizumab in Polypoidal Choroidal Vasculopathy|
- Best-corrected visual acuity [ Time Frame: up to 12 months ] [ Designated as safety issue: No ]Best-corrected visual acuity (BCVA) using the Snellen chart was evaluated including BCVA up to 12 months
- Angiographic characteristics [ Time Frame: up to 12 months ] [ Designated as safety issue: No ]Fluorescein angiography (FA) and ICGA (HRA; Heidelberg Engineering, Dossenheim, Germany) was evaluated. Greatest linear dimension (GLD) was determined based on both FA and ICGA.
Biospecimen Retention: Samples With DNA
Genomic DNA was extracted from peripheral blood. The two SNPs (rs10490924 in the LOC387715 locus and rs11200638 in HTRA1 gene) were analyzed by LC480 Real time PCR (Roche, Basel, Switzerland) at D&P Biotech (Daegu, Korea).
|Study Start Date:||October 2010|
|Study Completion Date:||August 2011|
|Primary Completion Date:||August 2011 (Final data collection date for primary outcome measure)|
polypoidal choroidal vasculopathy
patients who were treated for polypoidal choroidal vasculopathy with combined photodynamic therapy and intravitreal bevacizumab injections
This is a retrospective cohort study comprised of 70 eyes being treated for polypoidal choroidal vasculopathy with combined photodynamic therapy and intravitreal bevacizumab injections. Patients were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638).
|Korea, Republic of|
|In Taek Kim|
|Daegu, Kyungsangpookdo, Korea, Republic of, 700-721|
|Principal Investigator:||In Taek Kim, M.D.||Kyungpook National University|