Satiety Response of Four Dietary Fibers - Full Text View

Purpose

Studies have found a relationship between dietary fiber consumption and body weight regulation. This relationship may stem from enhanced satiety through fermentation of certain fibers in the large intestine.

The objective of this study is to determine and compare satiety ratings, changes in food intake, and gastrointestinal effects for four fibers: fructooligosaccharide, inulin, soluble corn fiber, and resistant starch.

Condition	Intervention	Phase
Healthy	Dietary Supplement: Control Dietary Supplement: Soluble corn fiber Dietary Supplement: Resistant starch Dietary Supplement: Fructooligosaccharide Dietary Supplement: Inulin	Phase 0

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator, Outcomes Assessor) Primary Purpose: Prevention
Official Title:	Satiety Response of Fructo-oligosaccharide (FOS), Inulin, Soluble Corn Fiber (SCF), and Resistant Starch (RS) in Overweight Woman and Relationship to Fermentation

Resource links provided by NLM:

MedlinePlus related topics: Dietary Fiber

Drug Information available for: Inulin

U.S. FDA Resources

Further study details as provided by University of Minnesota - Clinical and Translational Science Institute:

Primary Outcome Measures:

Satiety response using visual analogue scales [ Time Frame: 0, 15, 30, 45, 60, 90, 120, 180 minutes postprandially ] [ Designated as safety issue: No ]
Satiety response will be measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS).

Secondary Outcome Measures:

Food intake [ Time Frame: 180 minutes postprandially and over 24 hours ] [ Designated as safety issue: No ]
Breath hydrogen response [ Time Frame: 0 and 180 minutes ] [ Designated as safety issue: No ]
Gastrointestinal tolerance using visual analogue scales (VAS) [ Time Frame: 24 hours ] [ Designated as safety issue: No ]
Subjective ratings of bloating, stool consistency, and flatulence will be measured using VAS. A stool count will also be recorded.

Enrollment:	20
Study Start Date:	November 2010
Study Completion Date:	February 2012
Primary Completion Date:	February 2012 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Placebo Comparator: Low fiber control no treatment dinner bar, no treatment breakfast bar	Dietary Supplement: Control Dinner bar fortified with 0g fiber; breakfast bar fortified with 0g dietary fiber. Other Name: Low fiber control
Experimental: Promitor soluble corn fiber 12g in dinner bar, 11g in breakfast bar	Dietary Supplement: Soluble corn fiber Dinner bar fortified with 12g fiber; breakfast bar fortified with 11g dietary fiber. Other Name: Promitor soluble corn fiber
Experimental: FiberSym resistant starch 12g in dinner bar, 11g breakfast bar	Dietary Supplement: Resistant starch Dinner bar fortified with 12g fiber; breakfast bar fortified with 11g dietary fiber. Other Name: FiberSym resistant starch
Experimental: Orafti P95 fructooligosaccharide 12g in dinner bar, 11g in breakfast bar	Dietary Supplement: Fructooligosaccharide Dinner bar fortified with 12g fiber; breakfast bar fortified with 11g dietary fiber. Other Name: Orafti P95 fructooligosaccharide
Experimental: Orafti HPX inulin 12g in dinner bar, 11g in breakfast bar	Dietary Supplement: Inulin Dinner bar fortified with 12g fiber; breakfast bar fortified with 11g dietary fiber. Other Name: Orafti HPX inulin

Eligibility

Ages Eligible for Study:	18 Years to 40 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy women
Age 18-40 years
Nonsmoking
Not taking weight loss medications
Non-dieting (weight has not changed more than 11 pounds over three months)
BMI between 18.5 and 29
Spoken and written English literacy

Exclusion Criteria:

Do not regularly consume breakfast
Food allergies to wheat, soy, peanut, or dairy
BMI less than 25 or greater than 29 upon admission to study
Cancer diagnosis in past 5 years
History of heart disease, kidney disease, diabetes, or eating disorder
History of ulcerative colitis, Crohn's disease, or any other gastrointestinal condition
History of drug or alcohol abuse in past 6 months
Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication
Concurrent or recent (within 30 days) intervention study participation
Pregnant or lactating
Irregular menstrual cycle
Vegetarians
People who eat more than approximately 15 grams of fiber per day

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01233024

Locations

United States, Minnesota
University of Minnesota
Saint Paul, Minnesota, United States, 55108

Sponsors and Collaborators

University of Minnesota - Clinical and Translational Science Institute

Investigators

Principal Investigator:

Joanne L Slavin, PhD

University of Minnesota - Clinical and Translational Science Institute

More Information

No publications provided

Responsible Party:	University of Minnesota - Clinical and Translational Science Institute
ClinicalTrials.gov Identifier:	NCT01233024 History of Changes
Other Study ID Numbers:	1003E78714
Study First Received:	May 28, 2010
Last Updated:	March 28, 2012
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Minnesota - Clinical and Translational Science Institute:

Adult
Women
Dietary Fiber
Satiety Response
Food Intake

ClinicalTrials.gov processed this record on June 17, 2013