The Effect of Daily Dietary Intake of Dried Juice Concentrates of Fruit, Vegetables and Berries Upon Outcomes of Chronic Periodontitis (ENURGISE)

• Changes in clinical parameters [ Time Frame: 3 months ] [ Designated as safety issue: No ]

  The primary outcomes will be differences in the changes in the below parameters at 3-months post-supplementation between test and placebo groups:

  • % sites with marginal bleeding on probing (BOP) from baseline.
  • Probing pocket depth reductions (mm) from baseline (expressed as reductions in mean and also cumulative pocket depth).
  
  
• Changes in clinical parameters [ Time Frame: 6 months ] [ Designated as safety issue: No ]

  The primary outcomes will be differences in the changes in the parameters listed below at 6 months (3 months post supplementation + 3 months post treatment)in test and placebo groups

  % sites with marginal BOP from baseline. Probing pocket depth reductions (mm) from baseline (expressed as reductions in mean and also cumulative pocket depth).

  
  

• Clinical and biochemical changes [ Time Frame: 3 months ] [ Designated as safety issue: No ]

  Secondary outcome measures will be clinical and biochemical and include differences in the changes in the below between test and placebo groups:

  • Patient outcomes - oral health quality of life
  • Clinical outcomes - % sites BOP from pocket base from baseline, clinical attachment level (CAL) measures (mm), recession (mm), gingival redness (MGI).
  • Biochemical outcomes in plasma -carbonyls, 8OHdG (from buffy coats), isoprostanes, vitamin C, beta-carotene
  
  
• Clinical and biochemical changes [ Time Frame: 6 months ] [ Designated as safety issue: No ]

  Secondary outcome measures will be clinical and biochemical and include differences in the changes in the below between test and placebo groups:

  Patient outcomes - oral health quality of life Clinical outcomes - % sites BOP from pocket base from baseline, CAL measures (mm), recession (mm), gingival redness (MGI).

  Biochemical outcomes in plasma -carbonyls, 8OHdG (from buffy coats), isoprostanes, vitamin C, beta-carotene

  
  

The objective of this study is to determine whether enhanced micronutrient intake in the form of fruit, vegetable and berry juice powder (FVB) concentrate, improves clinical outcomes in chronic periodontitis patients prior to non-surgical treatment. In addition, the effects of supplementation prior to and following standard non-surgical management will be assessed, relative to a placebo supplemented group.

The investigators hypothesize that 3-months of nutritional support using this FVB will result in additional reductions in marginal gingival inflammation (bleeding) and additional reductions in probing pocket depth (mean & cumulative), over and above any placebo-related or behavioral effect. In addition, the investigators hypothesize that 3-months of nutritional support prior to a standard non-surgical therapy in conjunction with a continuation of the nutritional support for 3 months will result in further additional reductions in marginal gingival inflammation and probing pocket depth, over and above any placebo-related or behavioral effect following standard non-surgical therapy.