Resistance Exercise in Healthy Men

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Lex Verdijk, Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01220037
First received: October 7, 2010
Last updated: October 25, 2013
Last verified: October 2013
  Purpose

In the present study, the effects of age and dietary intake will be assessed on myocellular characteristics during 72 hours after a resistance type exercise session.


Condition Intervention
Single Bout of Resistance Type Exercise
Standardized Diet
Behavioral: Adhere to a specific standardized diet for 4 days

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Age and Dietary Protein Intake on Myocellular Characteristics Following a Single Bout of Resistance Exercise in Healthy Men

Resource links provided by NLM:


Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Muscle fiber myonuclear and stem cell content [ Time Frame: baseline ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 12 hours after a single bout of resistance type exercise ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 24 hours after a single bout of resistance type exercise ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 48 hours after a single bout of resistance type exercise ] [ Designated as safety issue: No ]
  • Muscle fiber myonuclear and stem cell content [ Time Frame: 72 hours after a single bout resistance type exercise ] [ Designated as safety issue: No ]

Enrollment: 34
Study Start Date: April 2010
Study Completion Date: December 2011
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Young regular diet
During the time of the study this group will adhere to a standardized regular diet.
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Young low protein diet
During the time of the study this group will adhere to a standardized low protein diet.
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Young high protein
During the time of the study this group will adhere to a standardized high protein diet.
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.
Experimental: Elderly
During the time of the study this group will adhere to a standardized high protein diet
Behavioral: Adhere to a specific standardized diet for 4 days
24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.

  Eligibility

Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men between the ages of 18-30 or 70-85 years

Exclusion Criteria:

  • Subjects with a recent history or current state of cardiovascular disease, COPD, Parkinson, rheumatoid arthritis, musculoskeletal/orthopaedic disorders, renal disorder, cognitive impairment.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01220037

Locations
Netherlands
Maastricht University Medical Centre
Maastricht, Zuid Limburg, Netherlands, 6200MD
Sponsors and Collaborators
Maastricht University Medical Center
  More Information

No publications provided by Maastricht University Medical Center

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Lex Verdijk, Dr., Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01220037     History of Changes
Other Study ID Numbers: MEC 09-3-080
Study First Received: October 7, 2010
Last Updated: October 25, 2013
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

ClinicalTrials.gov processed this record on July 22, 2014