Evaluation of the Impact of Embryo Biopsy on the Reproductive Potential of Embryos Undergoing In Vitro Fertilization (IVF)
To assess the impact of embryo biopsy on the reproductive potential of human embryos.
Each Patient is Both Case and Control
1 Embryo Will be Biopsied and 1 Embryo is Not
|Study Design:||Time Perspective: Prospective|
|Official Title:||Evaluation of the Impact of Embryo Biopsy on the Reproductive Potential of Embryos Undergoing IVF|
- Impact of biopsy on pregnancy [ Time Frame: 1 year ] [ Designated as safety issue: No ]Impact of the biopsy of the embryo on whether a pregnancy is obtained
- Impact of biopsy on delivery [ Time Frame: 1 year ] [ Designated as safety issue: No ]Impact of the biopsy on pregnancy resulting in delivery
Biospecimen Retention: Samples With DNA
Blood samples on female and male patients. Buccal swabs on infant(s).
|Study Start Date:||April 2008|
|Study Completion Date:||September 2012|
|Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
This study will recruit patients from the NY/NJ/CT/eastern PA area only.
All patients will undergo an in vitro fertilization (IVF) cycle with hormonal stimulation and an egg retrieval procedure as deemed appropriate for their diagnosis. Following biopsy, the embryos will be transferred. There will be no delay in the time of transfer as no cells will be analyzed prior to transfer.
On day 3 or day 5 of embryo development, all patients will undergo a two (2) embryo transfer. The embryos selected for transfer will be the 2 morphologically best of the embryo cohort. Once selected for transfer, the embryos will be randomized so that one will be biopsied and the other will be transferred without undergoing biopsy. The embryo randomized to biopsy will have a single cell biopsied.
Following delivery, buccal swabs will be collected from infants.
|United States, Connecticut|
|Reproductive Medicine Associates of Connecticut|
|Norfolk, Connecticut, United States, 06850|
|United States, New Jersey|
|Reproductive Medicine Associates of New Jersey|
|Morristown, New Jersey, United States, 07960|
|Reproductive Medicine Associates of New York|
|New York, New Jersey, United States, 10022|
|Principal Investigator:||Richard T Scott, MD||Reproductive Medicine Associates of New Jersey|