The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Taipei Medical University WanFang Hospital
ClinicalTrials.gov Identifier:
NCT01211041
First received: September 28, 2010
Last updated: April 21, 2011
Last verified: April 2011
  Purpose

Candida albicans is the most common and important clinical fungal pathogen. Our previous surveillance disclosed that fluconazole could induce different morphological changes in clinical strains. Our current study on C. albicans causing candiuria disclosed that renal insufficiency , diabetes mellitus, respiratory failure and uremia were risk factors of treatment failure. However, we also found results of E-test drug susceptible test could not predict outcome. Hence, retrospective analysis of 31 months period, cases that had C. albicans inducing candidemia were reviewed and 60 cases were enrolled for morphological study and potential virulent gene analysis.

This study is designed to clarity the clinical meaning of morphological form and virulent genes on candidemia. To do this study is probably helpful for treatment of candidiasis.


Condition
Candidemia Prognostic Factor and Mycobiological Analysis.

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia

Resource links provided by NLM:


Further study details as provided by Taipei Medical University WanFang Hospital:

Estimated Enrollment: 100
Study Start Date: July 2010
Estimated Study Completion Date: July 2011
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

case with candidemia of Candida albicans and candida caused the disease .

Criteria

Inclusion Criteria:

  • 2007 to 2010 medical records
  • Cases with candidemmia of Candida albicans with available clinical information in medical records for analysis.
  • Cases with candidemmia of Candida albicans which clinical isolates were preserved.

Exclusion Criteria:

  • Cases were not hospitalized for treatment and data were not available for analysis.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01211041

Contacts
Contact: Tsong-Yih Ou 886-2-29307930 ext 1760 93023@wanfang.gov.tw

Locations
Taiwan
Taipei Medical University - WanFang Hospital Recruiting
Taipei, Taiwan
Contact: Tsong-Yih Ou    886-2-29307930 ext 1760    93023@wanfang.gov.tw   
Sponsors and Collaborators
Taipei Medical University WanFang Hospital
Investigators
Principal Investigator: Tsong-Yih Ou Taipei Medical University WanFang Hospital
  More Information

No publications provided

Responsible Party: Tsong-Yih Ou, Infectious Disease Department
ClinicalTrials.gov Identifier: NCT01211041     History of Changes
Other Study ID Numbers: 99026
Study First Received: September 28, 2010
Last Updated: April 21, 2011
Health Authority: Taiwan: Department of Health

Keywords provided by Taipei Medical University WanFang Hospital:
Candida albicans, fungemia , prognostic factor

Additional relevant MeSH terms:
Fungemia
Candidemia
Sepsis
Infection
Mycoses
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Candidiasis, Invasive
Candidiasis

ClinicalTrials.gov processed this record on August 01, 2014