Post Cond No Reflow
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction|
- Extent of the area of microvascular obstruction [ Time Frame: 5 days ] [ Designated as safety issue: Yes ]Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group
- Size of the myocardial infarction [ Time Frame: 5 days ] [ Designated as safety issue: Yes ]Size of the myocardial infarction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group.
|Study Start Date:||April 2009|
|Study Completion Date:||March 2011|
|Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
No Intervention: Control
22 controls patients without post conditionment
22 posconditioned patients
Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01208727
|Hospices Civils de Lyon|
|Study Director:||Pierre CROISILLE, MD||Hospices Civils de Lyon|